Optogenetic application by using diverse rhodopsins of animals
| Project/Area Number |
25650117
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 光遺伝学 / Gタンパク質共役型受容体 / ロドプシン / Gタンパク質 / 情報伝達 |
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| Outline of Final Research Achievements |
Optogenetics is a technology that can control neural activity by light. Optogenetic potentials of three kinds of animal rhodopsins having the photoregeneration ability were investigated in the cultured cells. The results indicated that the rhodopsins having the photoregeneration ability were suitable for optogenetic tools. In addition, we found that mosquito Opn3 bound to 13-cis-retinal, which is ubiquitously present in animal bodies. The experimental data showed that the 13-cis-retinal binding ability and photoregeneration ability contributed to optogenetic application of mosquito Opn3.
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Report
(3 results)
Research Products
(45 results)
