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A search of novel surrogates of sterols in anaerobic eukaryotes

Research Project

Project/Area Number 25650132
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Evolutionary biology
Research InstitutionJapan Agency for Marine-Earth Science and Technology

Principal Investigator

TAKISHITA Kiyotaka  独立行政法人海洋研究開発機構, 海洋生物多様性研究分野, 主任研究員 (90392951)

Co-Investigator(Renkei-kenkyūsha) OHKOUCHI Naohiko  独立行政法人海洋研究開発機構, 生物地球化学研究分野, 分野長 (00281832)
CHIKARAISHI Yoshito  独立行政法人海洋研究開発機構, 生物地球化学研究分野, 主任研究員 (50455490)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords原生生物 / 嫌気 / 細胞膜 / ステロール
Outline of Final Research Achievements

It is known that sterols are associated with fluidity and permeability of eukaryotic cell membranes, and are key to fundamental eukaryotic-specific cellular processes such as phagocytosis. Several steps of de novo sterol biosynthesis require molecular oxygen. Our studies unveiled that some of eukaryotes inhabiting anoxic environments have neither sterols nor their structurally similar molecules based on analyses of genome, transcriptome, and GC-MS. However, it seems that the anaerobic eukaryotes in question can produce ceramides, in which a hydrophilic portion is very small compared with a hydrophobic portion as in the case of sterols, and the ceramides could be surrogates of sterols in these eukaryotes.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) Book (1 results)

  • [Journal Article] 有孔虫と放散虫を姉妹群とする「レタリア仮説」2015

    • Author(s)
      石谷佳之, 瀧下清貴
    • Journal Title

      化石

      Volume: 97 Pages: 13-21

    • NAID

      110009924175

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological identities of two different marine stramenopile environmental sequence clades: Bicosoeca kenaiensis (Hilliard 1971) and Cantina marsupialis (Larsen and Patterson, 1990) gen. nov., comb. nov.2015

    • Author(s)
      Naoji Yubuki, Tomas Panek, Akinori Yabuki, Ivan Cepicka, Kiyotaka Takishita, Yuji Inagaki, Brian S. Leander
    • Journal Title

      Journal of Eukaryotic Microbiology

      Volume: 62 Issue: 4 Pages: 532-542

    • DOI

      10.1111/jeu.12207

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lateral transfer of eukaryotic ribosomal RNA genes: an emerging concern for molecular ecology of microbial eukaryotes2014

    • Author(s)
      Akinori Yabuki
    • Journal Title

      ISME Journal

      Volume: 8 Issue: 7 Pages: 1544-1547

    • DOI

      10.1038/ismej.2013.252

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uncovering sibling species in Radiolaria: evidence for ecological partitioning in a marine planktonic protist2014

    • Author(s)
      Yoshiyuki Ishitani, Yurika Ujiie, Kiyotaka Takishita
    • Journal Title

      Molecular Phylogenetics and Evolution

      Volume: 78 Pages: 215-222

    • DOI

      10.1016/j.ympev.2014.05.021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Analyses of age and population genetic structure of the broadbanded thornyhead Sebastolobus macrochir in North Japan suggest its broad dispersion and migration before settlement2014

    • Author(s)
      Sakiko Orui Sakaguchi, Kiyotaka Takishita, Tomoaki Goto, Haruka Shibata, Shigeaki Kojima, Shinji Tsuchida, Hiroshi Kitazato, Katsunori Fujikura
    • Journal Title

      Journal of Oceanography

      Volume: 70 Issue: 5 Pages: 457-462

    • DOI

      10.1007/s10872-014-0240-x

    • NAID

      40020245569

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel alveolate in bivalves with chemosynthetic bacteria inhabiting deep-sea methane seeps2013

    • Author(s)
      Fumiya Noguchi, Masaru Kawato, Takao Yoshida, Yoshihiro Fujiwara, Katsunori Fujikura, Kiyotaka Takishita
    • Journal Title

      Journal of Eukaryotic Microbiology

      Volume: Vol.60 Issue: 2 Pages: 158-165

    • DOI

      10.1111/jeu.12017

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fine structure of Telonema subtilis Griessmann, 1913: a flagellate with a unique cytoskeletal structure among eukaryotes2013

    • Author(s)
      Akinori Yabuki
    • Journal Title

      Protist

      Volume: 164 Issue: 4 Pages: 556-569

    • DOI

      10.1016/j.protis.2013.04.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 酸素の無い環境に生息する真核生物の細胞膜および食作用にまつわるエトセトラ – 原始真核細胞モデル:嫌気性原生生物2013

    • Author(s)
      瀧下清貴
    • Journal Title

      細胞工学

      Volume: 32 Pages: 1286-1288

    • Related Report
      2013 Research-status Report
  • [Presentation] 嫌気性ストラメノパイル生物 Cantina marsupialis が有するミトコンドリア関連オルガネラの代謝能推定2015

    • Author(s)
      野口文哉, 島村繁, 中山卓郎, 矢崎裕規, 橋本哲男, 稲垣祐司, 藤倉克則, 瀧下清貴
    • Organizer
      日本藻類学会第39回大会
    • Place of Presentation
      九州大学,福岡県福岡市
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 珪藻寄生捕食性原生生物Hemistasia phaeocysticolaの系統分類学的研究2014

    • Author(s)
      矢吹彬憲
    • Organizer
      日本藻類学会
    • Place of Presentation
      東邦大学,千葉県
    • Related Report
      2013 Research-status Report
  • [Presentation] Ribosomal RNA gene laterally transferred from a perkinsid alveolate to Ciliophrys infusionum (Stramenopiles, Dictyochophyceae)2013

    • Author(s)
      Akinori Yabuki
    • Organizer
      The ICOP XIV - International Congress of Protistology
    • Place of Presentation
      The Westin Bayshore, Vancouver, CANADA
    • Related Report
      2013 Research-status Report
  • [Presentation] 不等毛植物門ディクティオカ藻綱Ciliophrys infusionumのゲノム断片より見いだされたrRNA遺伝子の水平伝搬2013

    • Author(s)
      矢吹彬憲
    • Organizer
      日本植物学会
    • Place of Presentation
      北海道大学,北海道
    • Related Report
      2013 Research-status Report
  • [Book] Marine Protists: Diversity and Dynamics2015

    • Author(s)
      Kiyotaka Takishita
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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