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A new technique which ebables the production of biofuel cells with high output

Research Project

Project/Area Number 25660083
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied biochemistry
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Mikawa Tsutomu  国立研究開発法人理化学研究所, 生命システム研究センター, 専任研究員 (20321820)

Research Collaborator IWASAKI Wakana  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 専任研究員 (00332289)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsバイオ燃料電池 / バイオテクノロジー / 酵素利用学 / バイオ電池
Outline of Final Research Achievements

Enzymatic biofuel cells, which mimic the metabolic pathway and employ oxidoreductases as catalysts, generate electricity when enzymes metabolize organic compounds. However, there are at least two issues to solve for the application. One is how efficiently enzymes are concentrated on electrodes, and the other is how efficiently extracted electrons are transferred to electrodes. In this study, I tried to resolve these issues by using enzyme crystals, in which enzymes are most concentrated, homogeneously located, and work normally. As a result, I have observed 10 times of current response for anode and 5 times of that for cathode. These results suggest that this new technique enables the production of a biofuel cell with high output.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Loop L1 governs the DNA-binding specificity and order for RecA-catalyzed reactions in homologous recombination and DNA repair2015

    • Author(s)
      Shinohara, T., Ikawa, S., Iwasaki, W., Hiraki, T., Hikima, T., Mikawa, T., Arai, N., Kamiya, N. and Shibata, T.
    • Journal Title

      Nucleic acids research

      Volume: 43 Issue: 2 Pages: 973-986

    • DOI

      10.1093/nar/gku1364

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Single molecule analysis of Thermus thermophilus SSB protein dynamics on single-stranded DNA2014

    • Author(s)
      Jichuan Zhang, Ruobo Zhou, Jin Inoue, Tsutomu Mikawa and Taekjip Ha
    • Journal Title

      Nucleic Acids Research

      Volume: 42 Issue: 6 Pages: 3821-3832

    • DOI

      10.1093/nar/gkt1316

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca2+ concentration in HeLa cells2013

    • Author(s)
      Dambarudhar Shiba Sankar Hembrama, Takahiro Haremakia, Jumpei Hamatsua, Jin Inouea, Hajime Kamoshidaa, Teppei Ikeyaa, Masaki Mishimaa, Tsutomu Mikawab, Nobuhiro Hayashic, Masahiro Shirakawad, Yutaka Ito
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 438 Issue: 4 Pages: 653-659

    • DOI

      10.1016/j.bbrc.2013.07.127

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] C-terminal deletion mutant of RecA conserves recombinase-activity, and the recombinase activity is enhanced by dATP2014

    • Author(s)
      飯倉ゆかり, 篠原赳, 笠置原央, 山口祐樹, 岩崎わかな, 柴田武彦, 美川務
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 組換え活性を向上させたRecA変異体を利用した高精度なPCR2014

    • Author(s)
      篠原 赳1, 飯倉 ゆかり, 重森 康司, 柴田 武彦, 美川 務
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 生命の代謝過程を模倣することにより発電するバイオ燃料電池の性能向上2014

    • Author(s)
      美川 務
    • Organizer
      第4回モデル生物丸ごと一匹学会
    • Place of Presentation
      豊中市 大阪大学会館
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] RecA二量体蛋白質のNMRによる構造機能解析2013

    • Author(s)
      山口 祐樹,飯倉 ゆかり,井上 仁,伊藤 隆,柴田 武彦,美川 務
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸市 神戸ポートアイランド
    • Related Report
      2013 Research-status Report
  • [Presentation] RecA 二量体蛋白質の NMRによる構造機能解析2013

    • Author(s)
      山口 祐樹,飯倉 ゆかり,井上 仁,伊藤 隆,柴田 武彦,美川 務
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      鳥取市 とりぎん文化会館
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 改変型の耐熱性RecA蛋白質、該タンパク質をコードする核酸分子、該タンパク質を用いた核酸の増幅方法、及び核酸増幅用キット2015

    • Inventor(s)
      重森康司、柴田武彦、美川 務、篠原 赳、飯倉ゆかり
    • Industrial Property Rights Holder
      アイシン精機、理化学研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 改変型の耐熱性RecA蛋白質、該タンパク質をコードする核酸分子、該タンパク質を用いた核酸の増幅方法、及び核酸増幅用キット2014

    • Inventor(s)
      重森康司,柴田武彦,美川 務,篠原 赳,飯倉ゆかり
    • Industrial Property Rights Holder
      アイシン精機(株),(独)理化学研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-07-24
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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