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Studies on roles of a newly identified hydrocephalus gene for maintenance in stem cells

Research Project

Project/Area Number 25660230
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionOsaka Prefecture University

Principal Investigator

KUWAMURA MITSURU  大阪府立大学, 生命環境科学研究科(系), 准教授 (20244668)

Co-Investigator(Renkei-kenkyūsha) Mori Nobuko  大阪府立大学, 理学研究科, 教授 (90100221)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords神経幹細胞 / 水頭症 / 細胞極性 / 上衣細胞 / 細胞増殖 / 細胞分化
Outline of Final Research Achievements

Ccdc85c is a causative gene for spontaneous mutant mouse with non-obstructive hydrocephalus. Ccdc85C was expressed in various simple epithelia but not stratified epithelia. Ccdc85C was localized at cell-cell junctions and its expression was strong at apical junctions. Intense expression was seen at developing period and gradually decreased with advancing development. Distribution of Ccdc85C coincides with that of proliferating epithelial cells. These results suggest that Ccdc85C plays an important role in the proliferative property of simple epithelia. In the canine mammary gland tumors, Ccdc85C was expressed at the apical junctions of the luminal epithelial cells and distributed throughout the entire cytoplasm of the myoepithelial cells. Ccdc85C expression was not observed at the epithelial cells forming sheet growth pattern. In the carcinomas, Ccdc85C expression in mammary tumor tissue tended to be weaker than that in surrounding normal mammary gland tissue.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats2015

    • Author(s)
      Tanaka M, Izawa T, Takenaka S, Yamate J, Kuwamura M.
    • Journal Title

      Histology and Histopathology

      Volume: 30 Pages: 823-832

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats2015

    • Author(s)
      Tanaka N, Izawa T, Takenaka S, Yamate J, Kuwamura M
    • Journal Title

      Histol Histopathol

      Volume: Feb 2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Ccdc85C expression in mammary gland tumors in animals2015

    • Author(s)
      Tanaka N, Izawa T, Yamate J, Kuwamura M
    • Organizer
      ACVP, ASVCP, and STP combined Annual Meeting
    • Place of Presentation
      ミネアポリスコンベンションセンター,ミネアポリス,米国
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] Hydrocephalus (Edt: Amaya Velazquez) Hemorrhagic hydrocephalus (hhy): a novel hydrocephalus mouse mutation with near-perfect penetrance2013

    • Author(s)
      Mori N, Kuwamura M, Tanaka N
    • Total Pages
      9
    • Publisher
      Nova Science Publishers, Inc
    • Related Report
      2013 Research-status Report
  • [Remarks] 大阪府立大学 獣医病理学教室 ホームページ

    • URL

      http://www.vet.osakafu-u.ac.jp/path/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 大阪府立大学 獣医病理学教室ホームページ

    • URL

      http://www.vet.osakafu-u.ac.jp/path/path.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 大阪府立大学 獣医病理学教室ホームページ

    • URL

      http://www.vet.osakafu-u.ac.jp/path/path.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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