Screening and characterization of factors regulating lifespan in fission yeast
Project/Area Number |
25660290
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied molecular and cellular biology
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Research Institution | Nagoya University |
Principal Investigator |
Aiba Hirofumi 名古屋大学, 創薬科学研究科, 教授 (60211687)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 分裂酵母 / 寿命 / 老化 / 健康長寿 |
Outline of Final Research Achievements |
In this study, we screened and characterized factors affecting chronological lifespan in fission yeast to gain insight how the lifespan of cell is regulated. We have succeeded to identify some novel factors whose recessive mutations result in the elongation of lifespan. Therefore if we could find reagent that inhibits function of the novel factor, we might be able to elongate fission yeast lifespan by treatment with such reagent. We also found genes whose over-expression result in the elongation of lifespan. Here we could accumulate basic knowledge for lifespan regulation of fission yeast.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] The Fission Yeast <i>php2</i> Mutant Displays a Lengthened Chronological Lifespan2013
Author(s)
Takuma, K., Ohtsuka, H., Azuma, K., Murakami, H. and Aiba, H
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 77
Issue: 7
Pages: 1548-1555
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Journal Article] Screening for long-lived genes identifies Oga1, a guanine-quadruplex associated protein that affects the chronological lifespan of the fission yeast Schizosaccharomyces pombe.2013
Author(s)
Ohtsuka, H., Ogawa, S., Kawamura, H., Sakai, E., Ichinose, K., Murakami, H. and Aiba, H
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Journal Title
Mol. Genet. Genomics
Volume: 288
Issue: 5-6
Pages: 285-295
DOI
Related Report
Peer Reviewed
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