| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we attempted to isolate the novel target proteins of NO using new screening system. In addition, we tried to identify the substrates of NO with several specific antibodies. We could isolate several enzymes involved in epigenetics as the targets of NO. We found that those candidates are S-nitrosylated in vitro and in vivo. These results indicated that those proteins are certainly the targets of NO. We are now investigated the role of S-nitrosylation on its enzymatic activity.
|
