Development of Protein-Protein Interaction Inhibitors
| Project/Area Number |
25670050
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
ICHIKAWA SATOSHI 北海道大学, 薬学研究科(研究院), 准教授 (60333621)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | タンパク質タンパク質間相互作用 / 薬物設計 / 有機合成 / 蛋白質間相互作用 / 化合物ライブラリー / 多成分反応 / 創薬化学 |
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| Outline of Final Research Achievements |
It is a quite important issue to develop a strategy for rational design of protein-protein interaction inhibitors (PPIs). In this study, a small library of PPIs with diverse structures was first designed and synthesized. We have found that several compounds inhibit a protein-protein interaction with a moderate activity. A larger set of library was further synthesized.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa.2014
Author(s)
Takeoka, Yusuke; Tanino, Tetsuya; Sekiguchi, Mitsuaki; Yonezawa, Shuji; Sakagami, Masahiro; Takahashi, Fumiyo; Togame, Hiroko; Tanaka, Yoshikazu; Takemoto, Hiroshi; Ichikawa, Satoshi*; Matsuda. Akira.
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Journal Title
ACS Med. Chem. Lett.
Volume: 5
Issue: 5
Pages: 556-560
DOI
Related Report
Peer Reviewed
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