Analysis of IGF-1 receptor-independent signaling from IGF-1 and its application for drug development
| Project/Area Number |
25670128
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
INUI Makoto 山口大学, 医学(系)研究科(研究院), 教授 (70223237)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Hiroki 山口大学, 大学院医学系研究科, 助教 (40464367)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 創傷治癒 / 細胞遊走 / インスリン様成長因子 / ペプチド / アンギオテンシン / 皮膚 / アンギオテンシンI変換酵素 / 角膜 |
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| Outline of Final Research Achievements |
Growth factors including insulin-like growth factor (IGF-1) play important roles in epithelial wound healing. We previously demonstrated that the C domain of IGF-1 as well as a tetrapeptides derived from the C domain, SSSR is responsible for the promotion of keratinocyte migration and cutaneous wound healing by IGF-1. Here we studied the molecular mechanisms of the action of SSSR in keratinocytes. We demonstrated that the promotion of keratinocyte migration by SSSR or IGF-1 did not require the IGF-1 receptor but rather was mediated by signaling from angiotensin II generated by angiotensin I-converting enzyme. Our results provide new insight into the action of IGF-1 in wound healing as well as a foundation for a potential new peptide-based treatment of skin wounds.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice.2015
Author(s)
Ishiguro S, Yoshimura K, Tsunedomi R, Oka M, Takao S, Inui M, Kawabata A, Wall T, Magafa V, Cordopatis P, Tzakos AG, Tamura M.
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Journal Title
Cancer Biol Ther.
Volume: 16
Issue: 2
Pages: 307-316
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A cell-penetrating phospholamban-specific RNA aptamer enhances Ca2+ transients and contractile function in cardiomyocytes.2014
Author(s)
Sakai, H., Ikeda, Y., Honda, T., Tanaka, Y., Shiraishi, K., and Inui, M.
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Journal Title
J. Mol. Cell. Cardiol.
Volume: 76
Pages: 177-185
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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