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Analysis of IGF-1 receptor-independent signaling from IGF-1 and its application for drug development

Research Project

Project/Area Number 25670128
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General pharmacology
Research InstitutionYamaguchi University

Principal Investigator

INUI Makoto  山口大学, 医学(系)研究科(研究院), 教授 (70223237)

Co-Investigator(Kenkyū-buntansha) SAKAI Hiroki  山口大学, 大学院医学系研究科, 助教 (40464367)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords創傷治癒 / 細胞遊走 / インスリン様成長因子 / ペプチド / アンギオテンシン / 皮膚 / アンギオテンシンI変換酵素 / 角膜
Outline of Final Research Achievements

Growth factors including insulin-like growth factor (IGF-1) play important roles in epithelial wound healing. We previously demonstrated that the C domain of IGF-1 as well as a tetrapeptides derived from the C domain, SSSR is responsible for the promotion of keratinocyte migration and cutaneous wound healing by IGF-1. Here we studied the molecular mechanisms of the action of SSSR in keratinocytes. We demonstrated that the promotion of keratinocyte migration by SSSR or IGF-1 did not require the IGF-1 receptor but rather was mediated by signaling from angiotensin II generated by angiotensin I-converting enzyme. Our results provide new insight into the action of IGF-1 in wound healing as well as a foundation for a potential new peptide-based treatment of skin wounds.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Int'l Joint Research] カンザス州立大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] イオアニア大学(ギリシャ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Signaling mechanism underlying the promotion of keratinocyte migration by angiotensin II2015

    • Author(s)
      Hiroki Sakai, Kenji Matsuura, Yoshie Tanaka, Takeshi Honda, Teruo Nishida, Makoto Inui
    • Journal Title

      Molecular Pharmacology

      Volume: 87 Issue: 2 Pages: 277-285

    • DOI

      10.1124/mol.114.096461

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peptide therapies for ocular surface disturbances based on fibronectin-integrin interactions.2015

    • Author(s)
      Nishida, T., Inui, M., and Nomizu, M.
    • Journal Title

      Progress in Retinal and Eye Research

      Volume: 47 Pages: 38-63

    • DOI

      10.1016/j.preteyeres.2015.01.004

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of angiotensin II type 2 receptor (AT2R) signaling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice.2015

    • Author(s)
      Ishiguro S, Yoshimura K, Tsunedomi R, Oka M, Takao S, Inui M, Kawabata A, Wall T, Magafa V, Cordopatis P, Tzakos AG, Tamura M.
    • Journal Title

      Cancer Biol Ther.

      Volume: 16 Issue: 2 Pages: 307-316

    • DOI

      10.1080/15384047.2014.1002357

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of B7-H3, a Potential Factor of Tumor Immune2014

    • Author(s)
      N.Maeda, K.Yoshimura,S.Yamamoto
    • Journal Title

      Ann Surg Oncol

      Volume: Epub ahead of print Issue: S4 Pages: 546-554

    • DOI

      10.1245/s10434-014-3564-2

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A cell-penetrating phospholamban-specific RNA aptamer enhances Ca2+ transients and contractile function in cardiomyocytes.2014

    • Author(s)
      Sakai, H., Ikeda, Y., Honda, T., Tanaka, Y., Shiraishi, K., and Inui, M.
    • Journal Title

      J. Mol. Cell. Cardiol.

      Volume: 76 Pages: 177-185

    • DOI

      10.1016/j.yjmcc.2014.09.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Regulation of adipocyte differentiation of 3T3-L1 cells by PDZRN32013

    • Author(s)
      Honda, T., Ishii, A., and Inui, M
    • Journal Title

      Am. J. Physiol. Cell Physiol

      Volume: 304 Issue: 11 Pages: C1091-C1097

    • DOI

      10.1152/ajpcell.00343.2012

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] IGF-1 promotes epithelial wound healing independently of the IGF-1 receptor via angiotensin II signaling.2016

    • Author(s)
      酒井大樹、松浦健二、本田健、西田輝夫、乾 誠
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Regulation of myogenic differentiation by PDZRN3 through modification of Id2 expression2016

    • Author(s)
      本田健、仲田成美、永井涼人、乾 誠
    • Organizer
      第89回日本薬理学会
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 皮膚創傷治癒過程におけるIGH-1と知覚神経由来のサブスタンスPとの協調作用のメカニズム2015

    • Author(s)
      酒井大樹、松浦健二、本田健、西田輝夫、乾 誠
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      下関市(海峡メッセ下関)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] スト細胞の走化性におけるトランスグルタミナーゼの役割2015

    • Author(s)
      倉増敦朗、武井光、乾 誠
    • Organizer
      第68回日本薬理学会西南部会
    • Place of Presentation
      下関市(海峡メッセ下関)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] SEK-1005による血管内皮細胞の遊走及び管腔形成促進効果

    • Author(s)
      酒井大樹、中島京、岩田博夫、乾 誠
    • Organizer
      日本循環薬理学会
    • Place of Presentation
      福岡大学(福岡市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Promotion of vascular endothelial cell migration and tube formation by SEK-1005.

    • Author(s)
      酒井大樹、中島京、岩田博夫、乾 誠
    • Organizer
      日本薬理学会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2022-02-01  

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