Identification of an endogenous oxidized LDL blocker and elucidation of its regulatory mechanism of arteriosclerotic diseases
| Project/Area Number |
25670133
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Shinshu University (2014-2015)
National Cardiovascular Center Research Institute (2013) |
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Principal Investigator |
KAKINO Akemi 信州大学, 先鋭領域融合研究群バイオメディカル研究所, 助教(特定雇用) (00534637)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 酸化LDL / 酸化LDL受容体 / 動脈硬化 |
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| Outline of Final Research Achievements |
Oxidized LDL (oxLDL) is implicated in atherosclerosis. Despite their potential importance, however, endogenous inhibitors that block the interaction between oxLDL and its receptors have not been extensively studied. To address this issue, we investigated whether developmental endothelial locus-1 (Del-1) might function as an endogenous inhibitor of oxLDL. Del-1 selectively bound to oxLDL. Del-1 inhibited oxLDL uptake and oxLDL-induced cellular responses irrespective of the kind of scavenger receptor. Moreover, Del-1 overexpression attenuated atherogenesis in mice. These results suggested that disrupted balance among modified LDL, scavenger receptors, and protective molecules might lead to the progression of atherosclerosis.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.2015
Author(s)
Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T and Rakugi H.
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Journal Title
The FASEB Journal
Volume: Apr 15
Issue: 8
Pages: 3342-3356
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lectin-like oxidized low-density lipoprotein recepto-r1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.2015
Author(s)
Nakayachi M, Ito J, Hayashida C, Ohyama Y, Kakino A, Okayasu M, Sato T, Ogasawara T, Kaneda T, Suda N, Sawamura T, Hakeda Y.
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Journal Title
Bone
Volume: 75
Pages: 170-182
Related Report
Peer Reviewed
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