Suggested common mechanism underlying between human Muse cells and planarian neoblasts
| Project/Area Number |
25670135
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
DEZAWA Mari 東北大学, 医学(系)研究科(研究院), 教授 (50272323)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 多能性幹細胞 / 線維芽細胞 / 間葉系幹細胞 / 結合組織 / 進化 / 繊維芽細胞 |
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| Outline of Final Research Achievements |
We identified HsDj2 in human Muse cells in immunoprecipitation using specific antibody to planarian neoblast. Splice variants expressed in human Muse cells were surveyed and 9 kinds of spriced forms were identified including full length. By comparing expression pattern in Muse and non-Muse MSC, 2 out of 9 subtypes were suggested to be selectively expressed only in Muse cells. Furthermore, by introducing siRNAs, exon 4 suppression in Muse cells promoted neural differentiation, and exon 6 suppression hepatocyte-lineage differentiation, suggesting that HsDj2 is pertinent to Muse cell pluripotency as well as to differentiation.
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Report
(3 results)
Research Products
(63 results)
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[Journal Article] Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2013
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera JJ, Kawashima R, Tominaga T, Dezawa M
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Journal Title
Cell Transplant
Volume: 22(9)
Issue: 9
Pages: 1613-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M
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Journal Title
J Clin Invest
Volume: 123(1)
Issue: 1
Pages: 272-284
DOI
Related Report
Peer Reviewed
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