| Project/Area Number |
25670160
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Institute of Health Sciences (2014-2015)
The University of Tokyo (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Shunichiro 帝京平成大学, 薬学部, 教授 (00260480)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 発毛 / 癌細胞 / 腫瘍細胞 / 増殖促進 / 毛乳頭細胞 / 網羅的解析 / 発毛因子 / ヌードマウス |
|---|
| Outline of Final Research Achievements |
The hair growth promotion in nude mouse by transplanting cancer cell line A was observed in this research. Global analysis of gene expression was performed using iTRAQ to identify hair growth factors, and expression altered genes by supplement of tumor cell extract were categorized based on gene ontology using DAVID Bioinformatics Resources. Upregulated genes were categorized into group related to mitochondria and calcium homeostasis. On the other hand, downregulated genes were categorized into group related to cell death. These factors play an essential role in hair growth and suppression of hair loss. Furthermore, culture supernatant of cancer cell line A promoted significantly to proliferation in human dermal papilla cells.
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