Research Project
Grant-in-Aid for Challenging Exploratory Research
The necessary of developing the technology of the ex vivo derivation of red blood cells from the cord blood hematopoietic stem cells or iPS cells as an alternative blood supply system has been recently emphasized. It is thus important to get a full picture of the molecular mechanisms underlying red blood cell differentiation in detail. In this study, I focused on a calcium-binding protein, CaBP, which is highly expressed during red blood cell differentiation, and tried to elucidate its physiological role in red blood cells by newly generating the hematopoietic lineage-specific CaBP-deficient mice. Furthermore, I determined the molecular mechanisms of CaBP-mediated regulation of erythroid differentiation. This study may provide the molecular basis for a novel regenerative medical technology for ex vivo manufacture of blood cell products.
All 2015 2014 2013 Other
All Journal Article (4 results) (of which Peer Reviewed: 4 results, Open Access: 3 results) Presentation (13 results) (of which Invited: 1 results) Book (2 results)
J Bone Miner Res.
Volume: 30 Issue: 5 Pages: 869-77
10.1002/jbmr.2418
Nat Commun
Volume: 6 Issue: 1 Pages: 6637-6637
10.1038/ncomms7637
Nature Medicine
Volume: 20 Issue: 1 Pages: 62-68
10.1038/nm.3432
J Immunol.
Volume: 191 Issue: 4 Pages: 1818-26
10.4049/jimmunol.1300379
