Understanding the mechanisms underlying erythroid differentiation and enucleation by using a novel mouse model of anemia and establishment of strategies to control their regulatory system
| Project/Area Number |
25670188
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKAMOTO Kazuo 東京大学, 医学(系)研究科(研究院), 助教 (00436643)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 赤血球 / 遺伝子改変マウス / 貧血 |
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| Outline of Final Research Achievements |
The necessary of developing the technology of the ex vivo derivation of red blood cells from the cord blood hematopoietic stem cells or iPS cells as an alternative blood supply system has been recently emphasized. It is thus important to get a full picture of the molecular mechanisms underlying red blood cell differentiation in detail. In this study, I focused on a calcium-binding protein, CaBP, which is highly expressed during red blood cell differentiation, and tried to elucidate its physiological role in red blood cells by newly generating the hematopoietic lineage-specific CaBP-deficient mice. Furthermore, I determined the molecular mechanisms of CaBP-mediated regulation of erythroid differentiation. This study may provide the molecular basis for a novel regenerative medical technology for ex vivo manufacture of blood cell products.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Genome-wide comprehensive analysis reveals critical cooperation between Smad and c-Fos in RANKL-induced osteoclastogenesis2015
Author(s)
Omata Y, Yasui T, Hirose J, Izawa N, Imai Y, Matsumoto T, Masuda H, Tokuyama N, Nakamura S, Tsutsumi S, Yasuda H, Okamoto K, Takayanagi H, Hikita A, Imamura T, Matsuo K, Saito T, Kadono Y, Aburatani H, Tanaka S
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Journal Title
J Bone Miner Res.
Volume: 30
Issue: 5
Pages: 869-77
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immune complexes regulate bone metabolism through FcRγ signalling2015
Author(s)
Negishi-Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 6637-6637
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.2014
Author(s)
Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, JA. and Takayanagi, H.
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Journal Title
Nature Medicine
Volume: 20
Issue: 1
Pages: 62-68
DOI
Related Report
Peer Reviewed / Open Access
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