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Understanding the mechanisms underlying erythroid differentiation and enucleation by using a novel mouse model of anemia and establishment of strategies to control their regulatory system

Research Project

Project/Area Number 25670188
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionThe University of Tokyo

Principal Investigator

OKAMOTO Kazuo  東京大学, 医学(系)研究科(研究院), 助教 (00436643)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords赤血球 / 遺伝子改変マウス / 貧血
Outline of Final Research Achievements

The necessary of developing the technology of the ex vivo derivation of red blood cells from the cord blood hematopoietic stem cells or iPS cells as an alternative blood supply system has been recently emphasized. It is thus important to get a full picture of the molecular mechanisms underlying red blood cell differentiation in detail. In this study, I focused on a calcium-binding protein, CaBP, which is highly expressed during red blood cell differentiation, and tried to elucidate its physiological role in red blood cells by newly generating the hematopoietic lineage-specific CaBP-deficient mice. Furthermore, I determined the molecular mechanisms of CaBP-mediated regulation of erythroid differentiation. This study may provide the molecular basis for a novel regenerative medical technology for ex vivo manufacture of blood cell products.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (13 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Genomewide comprehensive analysis reveals critical cooperation between smad and c-Fos in RANKL-induced osteoclastogenesis2015

    • Author(s)
      Omata Y, Yasui T, Hirose J, Izawa N, Imai Y, Matsumoto T, Masuda H, Tokuyama N, Nakamura S, Tsutsumi S, Yasuda H, Okamoto K, Takayanagi H, Hikita A, Imamura T, Matsuo K, Saito T, Kadono Y, Aburatani H, Tanaka S
    • Journal Title

      J Bone Miner Res.

      Volume: 30 Issue: 5 Pages: 869

    • DOI

      10.1002/jbmr.2418

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immune complexes regulate bone metabolism through FcRγ signalling2015

    • Author(s)
      Negishi-Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 6637-6637

    • DOI

      10.1038/ncomms7637

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.2014

    • Author(s)
      Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, JA. and Takayanagi, H.
    • Journal Title

      Nature Medicine

      Volume: 20 Issue: 1 Pages: 62-68

    • DOI

      10.1038/nm.3432

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical role of p38 and GATA3 in natural helper cell function.2013

    • Author(s)
      Furusawa J, Moro K, Motomura Y, Okamoto K, Zhu J, Takayanagi H, Kubo M, Koyasu S.
    • Journal Title

      J Immunol.

      Volume: 191 Issue: 4 Pages: 1818-26

    • DOI

      10.4049/jimmunol.1300379

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Regulation of osteoclastogenesis and erythropoiesis by the EF-hand protein, Efp2015

    • Author(s)
      岡本一男
    • Organizer
      第3回 Osteoclast Biology Meeting
    • Place of Presentation
      長野
    • Year and Date
      2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨細胞除去マウスの免疫細胞への影響2014

    • Author(s)
      寺島 明日香、岡本 一男、中島 友紀、高柳 広
    • Organizer
      第1回日本骨免疫会議
    • Place of Presentation
      沖縄
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Foxp3陽性T細胞から分化したTh17細胞の自己免疫性関節炎における重要性2014

    • Author(s)
      小松 紀子、岡本 一男、澤 新一郎、中島 友紀、田中 栄、高柳 広
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      沖縄
    • Year and Date
      2014-07-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] T細胞上のRANKLは、実験的自己免疫性脳脊髄炎におけるT細胞の中枢神経組織浸潤に関わる2014

    • Author(s)
      Guerrini Matteo、岡本 一男、中島 友紀、高柳 広
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      沖縄
    • Year and Date
      2014-07-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] EF-handタンパク質を介した破骨細胞分化と赤血球生成制御2014

    • Author(s)
      岡本 一男、林 幹人、中島 友紀、高柳 広
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      沖縄
    • Year and Date
      2014-07-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腿骨損傷後の骨再生におけるIL-17産生T細胞の役割2014

    • Author(s)
      小野 岳人、岡本 一男、高柳 広
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      沖縄
    • Year and Date
      2014-07-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis2014

    • Author(s)
      N. Komatsu, K. Okamoto, S. Sawa, T. Nakashima, M. Oh-hora, T. Kodama, S. Tanaka, J.A. Bluestone, and H. Takayanagi
    • Organizer
      5th International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Kos, Greece
    • Year and Date
      2014-06-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] RANKL licenses T lymphocytes to enter into the central nervous system in experimental autoimmune encephalomyelitis2014

    • Author(s)
      M.M. Guerrini, K. Okamoto, T. Nakashima, and H. Takayanagi
    • Organizer
      5th International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Kos, Greece
    • Year and Date
      2014-06-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulation of erythropoiesis by an EF-hand protein identified as a regulator of osteoclastogenesis2014

    • Author(s)
      K. Okamoto, M. Hayashi, T. Nakashima, and H. Takayanagi
    • Organizer
      5th International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Kos, Greece
    • Year and Date
      2014-06-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] T細胞が発現するRANKLは実験的自己免疫性脳脊髄炎の病態形成に重要である

    • Author(s)
      Matteo Guerrini、岡本一男、中島友紀、高柳広
    • Organizer
      第34回日本炎症・再生医学会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] RANKL expressed by T lymphocyte is needed for development of experimental autoimmune encephalomyelitis

    • Author(s)
      Matteo Guerrini、岡本一男、中島友紀、高柳広
    • Organizer
      第42会日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
  • [Presentation] 骨免疫学的視点からみたTh17細胞の機能

    • Author(s)
      岡本一男
    • Organizer
      日本小児リウマチ学会
    • Place of Presentation
      埼玉
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 自己免疫疾患の病態形成とTh17 細胞

    • Author(s)
      岡本一男
    • Organizer
      平成26年度 東京大学大学院医学系研究科病因・病理学専攻分野 博士課程説明会および若手講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] HORMONE FRONTIER IN GYNECOLOGY 骨の研究最前線 『骨免疫学』2013

    • Author(s)
      岡本一男、高柳広
    • Total Pages
      8
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Research-status Report
  • [Book] THE BONE 『骨代謝調節の新たな展開』2013

    • Author(s)
      岡本一男、高柳広
    • Total Pages
      7
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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