Trial of generating HIV-1-susceptible rhesus monkeys by using technologies in reproductive medicine

• Project/Area Number: 25670218
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Osaka University
• Principal Investigator: Shioda Tatsuo 大阪大学, 微生物病研究所, 教授 (00187329)
• Co-Investigator(Kenkyū-buntansha): AKARI Hirofumi 京都大学, 霊長類研究所, 教授 (20294671)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: HIV感染症 / iPS細胞 / 再生医療 / アカゲザル / iPS / CD4 / HIV-1 / 再生医療技術 / T細胞 / サル

Outline of Final Research Achievements

Currently it is impossible to eradicate HIV from infected individuals since HIV persists in resting memory T cells that have long half-life. Therefore, it is necessary to work out a totally novel strategy to eradicate HIV from infected individuals. To apply iPS cell technologies to HIV eradication strategies, we established iPS cells from peripheral blood mononuclear cells of rhesus monkeys. Human Oct3/4, Sox2, Klf4, and c-Myc genes worked in rhesus monkey cells for reprograming, although more stringent condition was required to establish rhesus monkey iPS cells. We were able to induce CD34+ hematopoietic stem cells and macrophage-like cells from the rhesus monkey iPS cells. We are now planning autologous transplantation of iPS cells with a marker into rhesus monkeys.

Research Products

• [Journal Article] Circulation of HIV-1 multiple complexity recombinant forms among female sex workers recently infected with HIV-1 in Thailand. (2016)
  • Author(s): Saeng-Aroon S, Loket R, Plipat T, Lumyai S, Chu P, Sangkitporn S, Nakayama EE, Takeda N, Shioda T, Motomura K.
  • Journal Title: AIDS Research and Human Retroviruses Volume: 0 Pages: 0-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection. (2016)
  • Author(s): Likanonsakul S, Suntisuklappon B, Nitiyanontakij R, Prasithsirikul W, Nakayama EE, Shioda T, Sangsajja C.
  • Journal Title: PLoS one Volume: 11 Issue: 1 Pages: e0147724-e0147724
  • DOI: 10.1371/journal.pone.0147724
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by randam mutagenesis. (2016)
  • Author(s): Sultana, T., Nakayama, E.E., Tobita, S., Yokoyama, M., Seki, Y., Saito, A., Nomaguchi, M., Adachi, A., Akari, H., Sato, H., and Shioda, T.
  • Journal Title: Journal of General Virology Volume: 97 Issue: 4 Pages: 963-976
  • DOI: 10.1099/jgv.0.000408
  • Peer Reviewed / Open Access
• [Journal Article] Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey. (2016)
  • Author(s): Suzuki S, Mori K, Higashino A, Iwasaki Y, Yasutomi Y, Maki N, Akari H
  • Journal Title: Microbiology and Immunology. Volume: 60 Issue: 1 Pages: 26-34
  • DOI: 10.1111/1348-0421.12349
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Impact of TRIM5α in vivo (2015)
  • Author(s): Nakayama EE, Shioda T
  • Journal Title: AIDS Volume: 29 Issue: 14 Pages: 1733-1743
  • DOI: 10.1097/qad.0000000000000812
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study of HIV-related lipoatrophy in Thai patients: Association of a DLGAP1 polymorphism with fat loss (2015)
  • Author(s): S. Uttayamakul, T. Oudot-Mellakh, E. E. Nakayama, P. Tengtrakulcharoen, J. Guergnon, J. F. Delfraissy, S. Khusmith, C. Sangsajja, S. Likanonsakul, I. Theodorou and T. Shioda
  • Journal Title: AIDS Res Hum Retroviruses Volume: 31 Issue: 8 Pages: 792-796
  • DOI: 10.1089/aid.2014.0266
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax. (2015)
  • Author(s): Ma G, Yasunaga J-I, Akari H, and Matsuoka M
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 112 Issue: 7 Pages: 2216-2221
  • DOI: 10.1073/pnas.1419198112
  • NAID: 120005537695
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Emergence of infectious malignant thrombocytopenia in Japanese macaques (Macaca fuscata) by SRV-4 after transmission to a novel host. (2015)
  • Author(s): Okamoto M, Miyazawa T, Morikawa S, Ono F, Nakamura S, Sato E, Yoshida T, Yoshikawa R, Sakai K, Mizutani T, Nagata N, Takano J, Okabayashi S, Hamano M, Fujimoto K, Nakaya T, Iida T, Horri T, Miyabe-Nishiwaki T, Watanabe A, Kaneko A, Saito A, Matsui A, Hayakawa T, Suzuki J, Akari H, Matsuzawa T, Hirai H.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 8850-8850
  • DOI: 10.1038/srep08850
  • Peer Reviewed / Open Access
• [Journal Article] Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers (2015)
  • Author(s): Takushi Nomura, Hiroyuki Yamamoto, Hiroshi Ishii, Hirofumi Akari, Taeko K. Naruse, Akinori Kimura, Tetsuro Matano
  • Journal Title: PLOS Pathogens Volume: 11 Issue: 11 Pages: e1005247-e1005247
  • DOI: 10.1371/journal.ppat.1005247
  • NAID: 120005763387
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fluorescent image analysis of HIV-1 and HIV-2 uncoating kinetics in the presence of old world monkey TRIM5α. (2015)
  • Author(s): Takeda E, Kono K, Hulme AE, Hope TJ, Nakayama EE, Shioda T.
  • Journal Title: PLoS ONE Volume: 10 Issue: 3 Pages: e0121199-e0121199
  • DOI: 10.1371/journal.pone.0121199
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The HIV-1 gp120/CXCR4 axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7. (2015)
  • Author(s): Hayasaka H, Kobayashi D, Yoshimura H, Nakayama EE, Shioda T, Miyasaka M.
  • Journal Title: PLoS ONE. Volume: 10 Issue: 2 Pages: 1371-1371
  • DOI: 10.1371/journal.pone.0117454
  • Peer Reviewed / Open Access
• [Journal Article] Distinct combinations of amino acid substitutions in N-terminal domain of Gag-capsid afford HIV-1 resistance to rhesus TRIM5α. (2014)
  • Author(s): Nomaguchi M, Nakayama EE,Yokoyama M, Doi N,Igarashi T, Shioda T, Sato H, Adachi A.
  • Journal Title: Microbes and Infection Volume: 16 Issue: 11 Pages: 936-944
  • DOI: 10.1016/j.micinf.2014.08.017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Demonstration of marmosets (Callithrix jacchus) as a non-human primate model for secondary dengue virus infection: high levels of viremia and serotype cross-reactive antibody responses consistent with secondary infection of humans (2014)
  • Author(s): Moi, M.L., Takasaki, T., Omatsu, T., Nakamura, S., Katakai, Y., Ami, Y., Suzaki, Y., Saijo, M., Akari, H. and Kurane, I.
  • Journal Title: Journal of General Virology Volume: 95 Issue: 3 Pages: 591-600
  • DOI: 10.1099/vir.0.060384-0
  • Peer Reviewed / Open Access
• [Journal Article] Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques (2014)
  • Author(s): Naruse TK, Akari H, Matano T, Kimura A.
  • Journal Title: Immunogenetics Volume: 66 Issue: 3 Pages: 161-170
  • DOI: 10.1007/s00251-014-0760-y
  • Peer Reviewed / Open Access
• [Journal Article] Seroprevalence of Japanese encephalitis virus infection in captive Japanese macaques (Macaca fuscata). (2014)
  • Author(s): Shimoda H, Saito A, Noguchi K, Terada Y, Kuwata R, Akari H, Takasaki T, Maeda K
  • Journal Title: Primates Volume: 55 Issue: 3 Pages: 441-445
  • DOI: 10.1007/s10329-014-0421-7
  • Peer Reviewed / Open Access
• [Journal Article] New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee blood. (2014)
  • Author(s): Fujie Y, Fusaki N, Katayama T, Hamasaki M, Soejima Y, Soga M, Ban H, Hasegawa M, Yamashita S, Kimura S, Suzuki S, Matsuzawa T, Akari H, Era T
  • Journal Title: PloS one Volume: 9 Issue: 12 Pages: 113052-113052
  • DOI: 10.1371/journal.pone.0113052
  • Peer Reviewed / Open Access
• [Journal Article] Moderate Restriction of Macrophage-Tropic Human Immunodeficiency Virus Type 1 by SAMHD1 in Monocyte-Derived Macrophages (2014)
  • Author(s): Taya K, Nakayama EE, Shioda T
  • Journal Title: PLoS One Volume: 9(3) Issue: 3 Pages: e90969-e90969
  • DOI: 10.1371/journal.pone.0090969
  • Peer Reviewed
• [Journal Article] Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors (2013)
  • Author(s): Nomaguchi M, Yokoyama M, Kono K, Nakayama EE, Shioda T, Doi N, Fujiwara S, Saito A, Akari H, Miyakawa K, Ryo A, Ode H, Iwatani Y, Miura T, Igarashi T, Sato H, Adachi A
  • Journal Title: J Virol Volume: 87(21) Issue: 21 Pages: 11447-11461
  • DOI: 10.1128/jvi.01549-13
  • Peer Reviewed
• [Journal Article] Slower Uncoating Is Associated with Impaired Replicative Capability of Simian-Tropic HIV-1 (2013)
  • Author(s): Kono K, Takeda E, Tsutsui H, Kuroishi A, Hulme AE, Hope TJ, Nakayama EE, Shioda T
  • Journal Title: PLoS One Volume: 8(8) Issue: 8 Pages: e72531-e72531
  • DOI: 10.1371/journal.pone.0072531
  • Peer Reviewed
• [Journal Article] TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1 (2013)
  • Author(s): Saito A, Nomaguchi M, Kono K, Iwatani Y, Yokoyama M, Yasutomi Y, Sato H, Shioda T, Sugiura W, Matano T, Adachi A, Nakayama E, Akari H
  • Journal Title: J Gen Virol Volume: 94(Pt 6) Issue: 6 Pages: 1318-24
  • DOI: 10.1099/vir.0.050252-0
  • Peer Reviewed
• [Journal Article] Systemic biological analysis of the mutations in two distinct HIV-1mt genomes occurred during replication in macaque cells (2013)
  • Author(s): Nomaguchi M, DOI N, Fujiwara S, Saito A, Akari H, Nakayama EE, Shioda T, Yokoyama M, Sato H, Adachi A
  • Journal Title: Microbes Infect Volume: 15(4) Issue: 4 Pages: 319-28
  • DOI: 10.1016/j.micinf.2013.01.005
  • Peer Reviewed
• [Journal Article] A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection (2013)
  • Author(s): Nakayama EE, Nakajima T, Kaur G, Mimaya JI, Terunuma H, Mehra N, Kimura A, Shioda T
  • Journal Title: AIDS Res Hum Retroviruses Volume: 29(6) Issue: 6 Pages: 919-24
  • DOI: 10.1089/aid.2012.0369
  • Peer Reviewed
• [Journal Article] Efficient in vivo depletion of CD8+ T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration (2013)
  • Author(s): Yoshida T, Suzuki S, Iwasaki Y, Kaneko A, Saito A, Enomoto Y, Higashino A, Watanabe A, Suzuki J, Inoue K, Kuroda T, Takada M, Ito R, Ito M, Akari H
  • Journal Title: Immunology Letters. Volume: 154 Issue: 1-2 Pages: 12-17
  • DOI: 10.1016/j.imlet.2013.08.005
  • Peer Reviewed
• [Journal Article] Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. (2013)
  • Author(s): Miura M, Yasunaga J-I, Tanabe J, Sugata K, Zhao T, Ma G, Miyazato P, Ohshima K, Kaneko A, Watanabe A, Saito A, Akari H and Matsuoka M
  • Journal Title: Retrovirology Volume: 10 Issue: 1 Pages: 118-118
  • DOI: 10.1186/1742-4690-10-118
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Macaque-tropic human immunodeficiency virus type 1 (HIV-1mt): Break out of the host factors. (2013)
  • Author(s): Saito A, Akari H
  • Journal Title: Frontiers in Microbiology Volume: 4 Pages: 187-187
  • DOI: 10.3389/fmicb.2013.00187
  • Peer Reviewed
• [Journal Article] Presence of Viral Genome in Urine and Development of Hematuria and Pathological Changes in Kidneys in Common Marmoset (Callithrix jacchus) after Inoculation with Dengue Virus (2013)
  • Author(s): Meng Ling Moi
  • Journal Title: Pathogens Volume: 2(2) Issue: 2 Pages: 357-363
  • DOI: 10.3390/pathogens2020357
  • Peer Reviewed
• [Journal Article] Dynamics of cellular immune responses in the acute phase of dengue virus infection (2013)
  • Author(s): Yoshida T, Omatsu T, Saito A, Katakai Y, Iwasaki Y, Kurosawa T, Hamano M, Higashino A, Nakamura S, Takasaki T, Yasutomi Y, Kurane I, Akari H
  • Journal Title: Archives of Virology Volume: 158 Issue: 6 Pages: 1209-1220
  • DOI: 10.1007/s00705-013-1618-6
  • NAID: 120005474482
  • Peer Reviewed
• [Presentation] Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis. (2016)
  • Author(s): Sultana T, Nakayama EE, Tobita S, Yokoyama M, Seki Y, Saito A, Nomaguchi M, Adachi A, Akari H, Sato H, Shioda T.
  • Organizer: The annual Conference on Retroviruses and Opportunistic Infections 2016
  • Place of Presentation: ボストン, USA
  • Year and Date: 2016-02-22
  • Int'l Joint Research
• [Presentation] テノフォビア服用による尿中ベータグロブリンの高値はABCC4遺伝子の一塩基多型と相関する (2015)
  • Author(s): 中山 英美, Sirirat Likanonsakul, Bussakorn Suntisuklappon, Ravee Nitiyanontakij, Pimrapat Tengtrakulcharoen, Wisit Prasithsirikul, Chariya Sangsajja, 塩田 達雄
  • Organizer: 第29回日本エイズ学会学術集会・総会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-30
• [Presentation] HIV-1 Gag p1ペプチドのウイルス生活環における機能的解析 (2015)
  • Author(s): 櫻木 小百合, 武田 英里, 塩田 達雄, 櫻木淳一
  • Organizer: 第29回日本エイズ学会学術集会・総会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-30
• [Presentation] R5指向性HIV-1mt感染カニクイザルによる新規エリートコントローラーモデルの開発 (2015)
  • Author(s): 関洋平、芳田剛、齊藤暁、佐藤賢文、原田恵嘉、吉村和久、渡部祐司、岩谷靖雅、保富康宏、俣野哲朗、三浦智行、明里宏文
  • Organizer: 第29回日本エイズ学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-30
• [Presentation] 高病原性SHIV感染サルにおいて、ART治療下で観察されたウイルスの減衰に関する検証 (2015)
  • Author(s): 渡部祐司、岩見真吾、森ひろみ、松浦嘉奈子、日紫喜隆行、三浦智行、明里宏文、五十嵐樹彦
  • Organizer: 第29回日本エイズ学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-30
• [Presentation] HIV-1 Gag p1ペプチドのウイルス生活環における機能的解析 (2015)
  • Author(s): 櫻木 小百合, 武田 英里, 塩田 達雄, 櫻木淳一
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] Novel mutant HIV-1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis (2015)
  • Author(s): Sultana Tahmina, Emi E. Nakayama, Satoshi Tobita, Akatsuki Saito, Masako Nomaguchi, Akio Adachi, Hirohumi Akari, Tatsuo Shioda
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] HIV-1mt感染カニクイザルによる新規エリートコントローラーモデル (2015)
  • Author(s): 関洋平、齊藤暁、芳田剛、佐藤賢文、原田恵嘉、吉村和久、渡部祐司、岩谷靖雅、保富康宏、俣野哲朗、三浦智行、明里宏文
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] 高病原性HIV感染サルにおいてウイルス感染CD163陽性マクロファージは様々な半減期を持つ集団から構成され、最も半減期の長い集団は多剤併用療法下のリザーバーと成り得る (2015)
  • Author(s): 渡部祐司、岩見真吾、森ひろみ、松浦嘉奈子、日紫喜隆行、三浦智行、明里宏文、五十嵐樹彦
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] 慢性GBV-B感染におけるenvelope変異および液性免疫からの逃避 (2015)
  • Author(s): 鈴木紗織、東濃篤徳、森健一、大出裕高、松岡和弘、岩谷靖雅、杉浦亙、片貝祐子、槇昇、明里宏文
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] 霊長類ヘパチウイルス慢性感染後寛解におけるウイルスゲノム変異の意義 (2015)
  • Author(s): 東濃篤徳、鈴木紗織、大出裕高、松岡和弘、森健一、片貝祐子、岡林佐知、槇昇、岩谷靖雅、杉浦亙、明里宏文
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-22
• [Presentation] Novel elite controller model by HIV-1mt-infected cynomolgus macaques. (2015)
  • Author(s): Yohei Seki, Akatsuki Saito, Takeshi Yoshida, Yorifumi Satou, Shigeyoshi Harada, Kazuhisa Yoshimura, Yuji Watanabe, Yasumasa Iwatani, Yasuhiro Yasutomi, Tetsuro Matano, Tomoyuki Miura, Hirofumi Akari
  • Organizer: 33rd Annual Symposium on NHP Models for AIDS
  • Place of Presentation: Monterey, USA
  • Year and Date: 2015-10-13
  • Int'l Joint Research
• [Presentation] Detection of potency and breadth of HIV-1 Neutralizing Antibodies in macaque-tropic HIV-1 infected cynomolgus monkeys using novel test panel viruses. (2015)
  • Author(s): Shigeyoshi Harada, Akatsuki Saito, Takeshi Yoshida, Yohei Seki, Yuji Watanabe, Yasumasa Iwatani, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, Hirofumi Akari, Kazuhisa Yoshimura
  • Organizer: 33rd Annual Symposium on NHP Models for AIDS
  • Place of Presentation: Monterey, USA
  • Year and Date: 2015-10-13
  • Int'l Joint Research
• [Presentation] Genetic and immunological escape in persistent GBV-B infection. (2015)
  • Author(s): Saori Suzuki, Atsunori Higashino, Ken-ichi Mori, Hirotaka Ode, Kazuhiro Matsuoka, Yasumasa Iwatani, Wataru Sugiura, Yuko Katakai, Noboru Maki, Hirofumi Akari
  • Organizer: 22nd International Symposium on Hepatitis C Virus and Related Viruses
  • Place of Presentation: Strasbourg, France
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] 新世界ザルにおける液性免疫応答の機能低下は霊長類肝炎ウイルスの持続感染に寄与する (2015)
  • Author(s): 鈴木紗織、東濃篤徳、森健一、大出裕高、松岡和弘、岩谷靖雅、杉浦亙、片貝祐子、槇昇、明里宏文.
  • Organizer: 第31回日本霊長類学会大会
  • Place of Presentation: 京都
  • Year and Date: 2015-07-18
• [Presentation] サル指向性HIV-1のin vivoにおける増殖効率を上昇させる要因 (2015)
  • Author(s): 関洋平、芳田剛、齊藤暁、松岡和弘、大出裕高、岩谷靖雅、保富康宏、俣野哲朗、三浦智行、杉浦亙、明里宏文
  • Organizer: 第62回日本実験動物学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-05-28
• [Presentation] HCVベースのHCV/GBV-Bキメラウイルスはタマリンへ長期感染する (2015)
  • Author(s): 鈴木紗織、東濃篤徳、森健一、片貝祐子、槇昇、明里宏文
  • Organizer: 第62回日本実験動物学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-05-28
• [Presentation] 小型霊長類において持続感染したヘパチウイルスゲノムの経時的変異 (2015)
  • Author(s): 東濃篤徳、鈴木紗織、森健一、大出裕高、松岡和弘、片貝祐子、岡林佐知、槇昇、岩谷靖雅、杉浦亙、明里宏文
  • Organizer: 第62回日本実験動物学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-05-28
• [Presentation] Host Factors in the Pathogenesis of HIV Infection. (2015)
  • Author(s): Tatsuo Shioda
  • Organizer: 17th International Conference on Emerging Infectious Diseases (EID) AIDS Panel Meeting
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-01-26 – 2015-01-29
  • Invited
• [Presentation] Genome-wide association study of HIV-related lipoatrophy in Thai patients: Association of a DLGAP1 polymorphism with fat loss. (2014)
  • Author(s): 中山英美, Uttayamakul Sumonmal, Tiphaine Oudot-Mellakh, Pimrapat Tengtrakulcharoen, Julien Guergnon, Jean-Francois Delfraissy, Srisin Khusmith,Chariya Sangsajja, Sirirat Likanonsakul, Ioannis Theodorou,塩田達雄
  • Organizer: 第28回日本エイズ学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] HIVパッケージングシグナル内最重要領域 SL1の機能的構造に関する多角的解析 (2014)
  • Author(s): 櫻木小百合,塩田達雄,櫻木淳一
  • Organizer: 第28回日本エイズ学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] TRIM5α存在下におけるHIV-1およびHIV-2のカプシドコアの脱殻 (2014)
  • Author(s): 武田英里,河野健,Amy E. Hulme,Thomas J.Hope,中山英美,塩田達雄
  • Organizer: 第28回日本エイズ学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] 再生医療技術のエイズ研究応用のためのアカゲザルiPS 細胞樹立とCD34陽性細胞への分化 (2014)
  • Author(s): 田谷かほる,武田英里,中山英美,塩田達雄,明里宏文,金子新
  • Organizer: 第28回日本エイズ学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] Novel mutant HIV-1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis (2014)
  • Author(s): Tahmina Sultana,中山英美, 飛田哲志,齊藤暁,明里宏文,塩田達雄
  • Organizer: 第28回日本エイズ学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-12-03 – 2014-12-05
• [Presentation] HIV-1パッケージングシグナル内最重要領域 SL1 の機能的構造に関する多角的解析 (2014)
  • Author(s): 櫻木淳一,櫻木小百合,塩田達雄
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] TRIM5α によるHIV-1 および HIV-2のカフプシトドコアの脱殻促進:可視化ウイルスによる解析 (2014)
  • Author(s): 武田英里,河野健, Amy E. Hulme, Thomas J. Hope, 中山英美,塩田達雄
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] Host factors in the pathogenesis of HIV infection. (2014)
  • Author(s): Tatsuo Shioda
  • Organizer: International Congress on Medical Virology 2014
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2014-11-05 – 2014-11-07
  • Invited
• [Presentation] Novel mutant HIV-1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis. (2014)
  • Author(s): Emi E Nakayama, Tetsushi Tobita, Tahmina Sultana, Akatsuki Saito, Hirofumi Akari, Tatsuo Shioda
  • Organizer: The 13th Awaji International Forum on Infection and Immunity in Nara
  • Place of Presentation: 奈良
  • Year and Date: 2014-09-23 – 2014-09-26
• [Presentation] レトロウイルスのGagAUG および翻訳とゲノムパッケージングに関する解析 (2013)
  • Author(s): 櫻木 淳一,夏井 洋和,櫻木 小百合,塩田 達雄
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] マクロファージ指向性 HIV-1も、マクロファージおよび単球において SAMHD1 による増殖抑制を受けている (2013)
  • Author(s): 田谷かほる、中山英美、塩田達雄
  • Organizer: 第27回日本エイズ学会学術集会・総会
  • Place of Presentation: 市民会館崇城大学ホール（熊本県）
• [Presentation] HIVサブタイプ比較によるゲノムパッケージングに関する解析 (2013)
  • Author(s): 櫻木淳一、櫻木小百合、塩田達雄
  • Organizer: 第27回日本エイズ学会学術集会・総会
  • Place of Presentation: 市民会館崇城大学ホール（熊本県）
• [Presentation] 可視化ウイルスをつかったHIV-2カプシドコアの脱核速度測定法の確立 (2013)
  • Author(s): 武田英里、河野健、Hulme Amy E.、Hope Thomas J.、中山英美、塩田達雄
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] レンチウイルスのGag開始コドンおよび翻訳とゲノムパッケージングに関する解析 (2013)
  • Author(s): 櫻木淳一、夏井洋和、櫻木小百合、塩田達雄
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Moderate restriction of macrophage tropic human immunodeficiency virus type 1 by SAMHD1 in monocyte-derived macrophages. (2013)
  • Author(s): Kahoru Taya, Emi E Nakayama, Shioda Tatsuo
  • Organizer: 第12回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県）
• [Presentation] Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1. (2013)
  • Author(s): Eri Takeda, Ken Kono, Hiromi Tsutsui, Ayumu Kuroishi, Amy E. Hulme, Thomas J. Hope, Emi. E Nakayama, Tatsuo Shioda
  • Organizer: 第12回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県）
• [Presentation] Relationship between genome packaging and Gag translation of various mammal retroviruses. (2013)
  • Author(s): Sayuri Sakuragi, Hirokazu Natsui, Tatsuo Shioda, Jun-ichi Sakuragi
  • Organizer: The 25th Workshop on Retroviral Pathogenesis
  • Place of Presentation: アイスランド大学（アイスランド）