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Essential trial to achieve blood RNA diagnosis based on gene expression profiles

Research Project

Project/Area Number 25670282
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Takahashi Junko  国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (80415702)

Co-Investigator(Kenkyū-buntansha) IWAHASHI Hitoshi  岐阜大学, 応用生物科学部・分子生命科学コース, 教授 (60356540)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords血液診断 / RNA診断
Outline of Final Research Achievements

Now, the RNA diagnosis requires standardization of procedure for making reproducible samples.In blood, we may find huge information concern to physiological conditions of organ and tissue, in addition to function of RNAs. These technologies can be achieved owing to next-generation DNA sequencer. To support those technologies, we studied the evaluation procedures for quality of prepared RNA and for identification of original organ in blood RNA.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2016 2015 2013

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Gene expression profiling can predict the fate of HeLa cells exposed to X-ray irradiation with or without protoporphyrin accumulation2015

    • Author(s)
      J. Takahashi, M. Misawa, H. Iwahashi
    • Journal Title

      Genomics Data

      Volume: 5 Pages: 192-194

    • DOI

      10.1016/j.gdata.2015.05.044

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation for Integrity of Extracted RNA by Reference Material of RNA2013

    • Author(s)
      Junko Takahashi1, Akiko Takatsu, Hitoshi Iwahashi
    • Journal Title

      Journal of Medical Diagnostic Methods

      Volume: 2:128 Issue: 03 Pages: 1-5

    • DOI

      10.4172/2168-9784.1000128

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 標準RNAを用いた抽出RNAのクオリティコントロール2016

    • Author(s)
      長谷川 丈真、高橋 淳子、 岩橋 均
    • Organizer
      日本農芸化学会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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