| Project/Area Number |
25670308
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | 公益財団法人大阪府保健医療財団大阪がん循環器病予防センター(予防推進部・循環器病予防健診部・健康開発 |
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Principal Investigator |
Kawasaki Ryo 公益財団法人大阪府保健医療財団大阪がん循環器病予防センター(予防推進部・循環器病, その他部局等, その他 (70301067)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGISHI Kazumasa 筑波大学, 医学医療系, 講師 (20375504)
ISO Hiroyasu 大阪大学, 医学系研究科, 教授 (50223053)
TANIGAWA Takeshi 順天堂大学, 医学系研究科, 教授 (80227214)
KITAMURA Akihiko 大阪がん循環器病予防センター, その他 (80450922)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 網膜血管 / 睡眠呼吸障害 / 危険因子 / 肥満 / 動脈硬化 / 予防 / 睡眠 / 網膜 / 医用画像 / 予防医学 / 循環器疾患 |
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| Outline of Final Research Achievements |
We examined whether sleep-disordered breathing (SDB) is associated with microvascular damage as a link causing cardiovascular diseases. In the circulatory Risks in communities study (CIRCS), we first digitized film-based fundus images and then measured retinal vascular calibres. After adjusting for age, sex, smoking, alcohol consumption, total cholesterol, triglycerides, systolic blood pressure, those who experienced more than 5 times of 3% reduction in the oxygen desaturation index (ODI) per hour had significantly larger retinal venular calibre compared to those who had less than 5 times of 3%ODI. However, further adjustment with body mass index attenuated this association to a non-significant level. This attenuation is explained by known strong association of BMI and retinal veno-dilation; the association between SDB and retinal veno-dilation can be mostly explained by the association between BMI and veno-dilation.
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