| Project/Area Number |
25670309
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene and public health
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | ナノ粒子 / 酸化チタン / 食品添加物 / 免疫応答 / 免疫抑制 / マウス / 経消化管投与 |
|---|
| Research Abstract |
We prepared the animal pellet food contained nano size particles (20nm and 200nm) of titanium oxide and gave to experimental mice for 50 days. After the exposure period, we obtained the spleen and prepared single cell suspension and used for the basic test of immune responses. We detected the immune oppressive effect among 20nm titanium oxide particle exposed group in dose-dependently although it was not significant. At the standing point of view of food safety, we have better to evaluate the effects on local immune system/response such as gastrointestinal immunity of nano size titanium oxide particles.
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