Inhibitory role of a hemoglobin-derived peptide hemopressin in stress pathway

• Project/Area Number: 25670354
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kochi University
• Principal Investigator: TANAKA Kenjiro 高知大学, 教育研究部医療学系, 助教 (30552260)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Takahiro 高知大学, 教育研究部医療学系, 准教授 (00363276) ; NAKAMURA Kumiko 高知大学, 教育研究部医療学系, 技術専門職員 (30398052)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ヘモプレシン / ストレス / カンナビノイド

Outline of Final Research Achievements

This study exhibited that RVD-hemopressin, a hemoglobin-derived peptide, inhibited the activition of sympatho-adrenomedullary outflow through brain cannabinoid CB1 receptors. We also represented a possibility that spinally projecting (pre-sympathetic) hemoglobin-containing neurons of the hypothalamic paraventricular nucleus contribute to a central modulation of sympatho-adrenomedullary outflow. These findings provide basic data for the therapeutic use of RVD-hemopressin in the central regulation of stress response.

Research Products

• [Journal Article] Possible inhibitory role of endogenous 2-arachidonoylglycerol as an endocannabinoid in (±)-epibatidine-induced activation of central adrenomedullary outflow in the rat. (2015)
  • Author(s): Shimizu T, Tanaka K, Shimizu S, Higashi Y, Yawata T, Nakamura K, Taniuchi K, Ueba T, Yuri K, Saito M
  • Journal Title: Neuropharmacology Volume: 95 Pages: 278-289
  • DOI: 10.1016/j.neuropharm.2015.03.034
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Brain RVD-haemopressin, a haemoglobin-derived peptide, inhibits bombesin-induced central activation of adrenomedullary outflow in the rat (2014)
  • Author(s): Tanaka K, Shimizu T, Yanagita T, Nemoto T, Nakamura K, Taniuchi K, Dimitriadis F, Yokotani K, Saito M
  • Journal Title: Br. J. Pharmacol. Volume: 171 Issue: 1 Pages: 202-213
  • DOI: 10.1111/bph.12471
  • Peer Reviewed
• [Journal Article] Central bombesin possibly induces S-nitrosylation of cyclooxygenase-1 in pre-sympathetic neurons of rat hypothalamic paraventricular nucleus (2014)
  • Author(s): Tanaka K, Shimizu T, Higashi Y, Nakamura K, Taniuchi K, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
  • Journal Title: Life Sci. Volume: 100 Issue: 2 Pages: 85-96
  • DOI: 10.1016/j.lfs.2014.01.079
  • Peer Reviewed
• [Journal Article] Possible involvement of brain prostaglandin E2 and prostanoid EP3 receptors in prostaglandin E2 glycerol ester-induced activation of central sympathetic outflow in the rat (2014)
  • Author(s): Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yawata T, Higashi Y, Ueba T, Dimitriadis F, Shimizu S, Yokotani K, Saito M.
  • Journal Title: Neuropharmacology Volume: 82 Pages: 19-27
  • DOI: 10.1016/j.neuropharm.2014.03.005
  • Peer Reviewed / Open Access
• [Presentation] Expression of hemoglobin in presympathetic neurons of rat hypothalamic paraventricular nucleus with bombesin-induced activation (2015)
  • Author(s): Kenjiro Tanaka, Kazunari Yuri
  • Organizer: 第120回 日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Centrally administered bombesin activates hemoglobin-containing pre-sympathetic neurons in rat hypothalamic paraventricular nucleus (2014)
  • Author(s): Kenjiro Tanaka, Takahiro Shimizu, Motoaki Saito, Kazunari Yuri
  • Organizer: 第37回 日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川）
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] ボンベシン脳室内投与により活性化したラット視床下部室傍核前交感神経性ニューロンにおけるヘモグロビンおよびヘモグロビン由来ペプチドの発現 (2014)
  • Author(s): 田中健二朗、清水孝洋、谷内恵介、中村久美子、横谷邦彦、齊藤源顕
  • Organizer: 第87回 日本薬理学会年会
  • Place of Presentation: 東北大学百周年記念会館川内萩ホール・仙台国際センター（宮城）
• [Presentation] ラット視床下部室傍核へ投与されたボンベシンによる中枢性交感神経系-副腎髄質系賦活に対し脳内カンナビノイドCB1受容体は抑制性に関与する (2014)
  • Author(s): 清水孝洋、田中健二朗、中村久美子、谷内恵介、清水翔吾、八幡俊男、東洋一郎、上羽哲也、横谷邦彦、齊藤源顕
  • Organizer: 第87回 日本薬理学会年会
  • Place of Presentation: 東北大学百周年記念会館川内萩ホール・仙台国際センター（宮城）
• [Presentation] ラット視床下部室傍核へ投与されたボンベシンにより惹起された中枢性交感神経-副腎髄質系賦活に対する脳内カンナビノイドCB1受容体の抑制性関与 (2014)
  • Author(s): 清水孝洋、田中健二朗、中村久美子、谷内恵介、清水翔吾、八幡俊男、東洋一郎、上羽哲也、横谷邦彦、齊藤源顕
  • Organizer: 日本薬学会 第134年会
  • Place of Presentation: ホテル日航熊本・熊本大学黒髪キャンパス・熊本市総合体育館（熊本）