| Project/Area Number |
25670354
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kochi University |
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Principal Investigator |
TANAKA Kenjiro 高知大学, 教育研究部医療学系, 助教 (30552260)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takahiro 高知大学, 教育研究部医療学系, 准教授 (00363276)
NAKAMURA Kumiko 高知大学, 教育研究部医療学系, 技術専門職員 (30398052)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ヘモプレシン / ストレス / カンナビノイド |
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| Outline of Final Research Achievements |
This study exhibited that RVD-hemopressin, a hemoglobin-derived peptide, inhibited the activition of sympatho-adrenomedullary outflow through brain cannabinoid CB1 receptors. We also represented a possibility that spinally projecting (pre-sympathetic) hemoglobin-containing neurons of the hypothalamic paraventricular nucleus contribute to a central modulation of sympatho-adrenomedullary outflow. These findings provide basic data for the therapeutic use of RVD-hemopressin in the central regulation of stress response.
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