Identification of SNPs on mature micro RNA to analyze origin of miRNA

• Project/Area Number: 25670369
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Hiroshima University
• Principal Investigator: CHAYAMA Kazuaki 広島大学, 医歯薬保健学研究院, 教授 (00211376)
• Project Period (FY): 2013-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 肝臓学 / SNP / digital PCR / microRNA / transplantation

Research Abstract

Recent research made it clear that there are certain amount of circulating miRNA in serum, which present in serum associated with proteins such as AGO1 and AGO2. Such AGO-protein bound miRNA is quite stable and detectable by polymerase chain reaction after extraction from the serum samples and reverse transcription. We attempted to analyze organs which secrete each miRNA by analyzing circulating miRNA that is present in serum samples. To perform this analysis we tried to identify SNPs that is present in miRNA. We searched for such SNP in entire human genome analyzing human genome database and identified several candidate SNPs. Although we attempted to detect such miRNA with digital PCR, detection of small amount of miRNA was quite difficult. Further study is needed to detect such small amount of miRNA in serum samples.

Research Products

• [Journal Article] Letter : Pitavastatin supplementation of PEG-IFN/ribavirin improves sustained virological response against HCV (2014)
  • Author(s): Yokoyama S, Kawakami Y, and Chayama K
  • Journal Title: Aliment Pharmacol Ther Volume: 39 Issue: 4 Pages: 4-443
  • DOI: 10.1111/apt.12605
  • Peer Reviewed / Open Access
• [Journal Article] Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection (2014)
  • Author(s): Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, Kawakami Y, Ido A, Yamamoto K, Takaguchi K, Izumi N, Koike K, Takehara T, Kawada N, Sata M, Miyagoshi H, Eley T, McPhee F, Damokosh A, Ishikawa H, and Hughes E
  • Journal Title: Hepatology Volume: (in press) Issue: 6 Pages: 2083-2091
  • DOI: 10.1002/hep.27113
  • Peer Reviewed / Open Access
• [Journal Article] Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial (2014)
  • Author(s): Yokoyama S. Takahashi S. Kawakami Y. Hayes C N. Kohno H. Kohno H. Tsuji K. Aisaka Y. Kira S. Yamashina K. Nonaka M. Moriya T. Kitamoto M. Aimitsu S. Nakanishi T. Kawakami H, and Chayama K
  • Journal Title: J Viral Hepat Volume: 21 Issue: 5 Pages: 348-56
  • DOI: 10.1111/jvh.12146
  • Peer Reviewed / Open Access
• [Journal Article] Non-invasive liver fibrosis score calculated by combination of virtual touch tissue quantification and serum liver functional tests in chronic hepatitis C patients (2014)
  • Author(s): Takaki S. Kawakami Y. Miyaki D. Nakahara T. Naeshiro N. Murakami E. Tanaka M. Honda Y. Yokoyama S. Nagaoki Y. Kawaoka T. Hiramatsu A. Tsuge M. Hiraga N. Imamura M. Hyogo H. Aikata H. Takahashi S. Arihiro K, and Chayama K
  • Journal Title: Hepatol Res Volume: 44 Issue: 3 Pages: 280-7
  • DOI: 10.1111/hepr.12129
  • Peer Reviewed / Open Access
• [Journal Article] Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer (2014)
  • Author(s): Takahashi Y. Ando M. Nishikawa M. Hiraga N. Imamura M. Chayama K, and Takakura Y
  • Journal Title: Hum Gene Ther Clin Dev Volume: 25 Issue: 1 Pages: 28-39
  • DOI: 10.1089/humc.2013.066
  • Peer Reviewed / Open Access
• [Journal Article] A randomized trial of daclatasvir with peginterferon alfa-2b and ribavirin for HCV genotype 1 Infection. (2014)
  • Author(s): Suzuki F, Toyoa J, Ikeda K, Chayama K, Mochida S, Hayashi N, Ishikawa H, Miyagoshi H, Hu W, McPhee F, Hughes
  • Journal Title: Antiviral Ther Volume: in press Issue: 5 Pages: 491-499
  • DOI: 10.3851/imp2730
  • Peer Reviewed
• [Journal Article] interferon lambda 4/interleukin-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population (2014)
  • Author(s): Ochi H, Miki D, Hayes CN, Abe H, Hayashida Y, Kubo M, Chayama K
  • Journal Title: Journal of General Virology Volume: 95巻 Issue: 6 Pages: 1297-306
  • DOI: 10.1099/vir.0.060103-0
  • Peer Reviewed
• [Journal Article] Virologic escape in HCV genotype 1-infected patients receiving daclatasvir plus ribavirin and peginterferon alfa-2a or alfa-2b. (2014)
  • Author(s): McPhee F. Hernandez D. Zhou N. Yu F. Ueland J. Monikowski A. Chayama K. Toyota J. Izumi N. Yokosuka O. Kawada N. Osaki Y. Hughes E A. Watanabe H. Ishikawa H, and Kumada H
  • Journal Title: Antivir Ther Volume: 印刷中 Issue: 5 Pages: 479-490
  • DOI: 10.3851/imp2729
  • Peer Reviewed
• [Journal Article] Targeted next-generation sequencing and fine linkage disequilibrium mapping reveals association of PNPLA3 and PARVB with the severity of nonalcoholic fatty liver disease (2014)
  • Author(s): Kitamoto T, Kitamoto A, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, Nakao K, Sekine A, Chayama K, Nakajima A, Hotta K
  • Journal Title: Journal of Human Genetics Volume: 6 Issue: 5 Pages: 241-6
  • DOI: 10.1038/jhg.2014.17
  • NAID: 120005477223
  • Peer Reviewed
• [Journal Article] Two patients treated with pegylated interferon/ribavirin/telaprevir triple therapy for recurrent hepatitis C after living donor liver transplantation. (2014)
  • Author(s): Kawaoka T. Takahashi S. Tatsukawa Y. Hiramatsu A. Hiraga N. Miki D. Tsuge M. Imamura M. Kawakami Y. Aikata H. Ochi H. Ishiyama K. Ide K. Tashiro H. Ohdan H, and Chayama K
  • Journal Title: Hepatol Res Volume: 印刷中 Issue: 12 Pages: 1259-1264
  • DOI: 10.1111/hepr.12296
  • Peer Reviewed / Open Access
• [Journal Article] Clinical outcome and prognostic factors of patients with hepatocellular carcinoma and extrahepatic metastasis treated with sorafenib. (2014)
  • Author(s): Kawaoka T. Aikata H. Kan H. Fujino H. Fukuhara T. Kobayashi T. Naeshiro N. Miyaki D. Hiramatsu A. Imamura M. Kawakami Y. Hyogo H, and Chayama K
  • Journal Title: Hepatol Res Volume: 印刷中 Issue: 13 Pages: 1320-1328
  • DOI: 10.1111/hepr.12307
  • Peer Reviewed / Open Access
• [Journal Article] Noninvasive assessment of liver steatosis in nonalcoholic fatty liver disease. (2014)
  • Author(s): Kan H. Kimura Y. Hyogo H. Fukuhara T. Fujino H. Naeshiro N. Honda Y. Kawaoka T. Tsuge M. Hiramatsu A. Imamura M. Kawakami Y. Aikata H. Ochi H. Arihiro K, and Chayama K
  • Journal Title: Hepatol Res Volume: 印刷中 Issue: 14
  • DOI: 10.1111/hepr.12330
  • Peer Reviewed / Open Access
• [Journal Article] A comparative study of 4 Fr versus 6 Fr nasobiliary drainage catheters: a randomized, controlled trial. (2014)
  • Author(s): Ishigaki T. Sasaki T. Serikawa M. Minami T. Okazaki A. Yukutake M. Ishii Y. Kosaka K. Mouri T. Yoshimi S, and Chayama K
  • Journal Title: J Gastroenterol Hepatol Volume: 29 Issue: 3 Pages: 653-9
  • DOI: 10.1111/jgh.12427
  • Peer Reviewed / Open Access
• [Journal Article] Serum asymmetric dimethylarginine levels are independently associated with procollagen III N-terminal peptide in nonalcoholic fatty liver disease patients. (2014)
  • Author(s): Hyogo H. Yamagishi S. Maeda S. Fukami K. Ueda S. Okuda S. Nakahara T. Kimura Y. Ishitobi T, and Chayama K
  • Journal Title: Clin Exp Med Volume: 14 Issue: 1 Pages: 45-51
  • DOI: 10.1007/s10238-012-0223-4
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin 28B polymorphism predicts interferon plus ribavirin treatment outcome in patients with hepatitis C virus-related liver cirrhosis: A multicenter retrospective study in Japan. (2014)
  • Author(s): Shakado S, Sakisaka S, Okanoue T, Chayama K, Izumi N, Toyoda J, Tanaka E, Ido A, Takehara T, Yoshioka K, Hiasa Y, Nomura H, Seike M, Ueno Y, Kumada H.
  • Journal Title: Hepatol Res Volume: 44 Issue: 9 Pages: 983-992
  • DOI: 10.1111/hepr.12280
  • Peer Reviewed / Open Access
• [Journal Article] Combination therapies with NS5A, NS3 and NS5B inhibitors on different genotypes of hepatitis C virus in human hepatocyte chimeric mice (2013)
  • Author(s): Shi, N. Hiraga, N. Imamura, M. Hayes, C. N. Zhang, Y. Kosaka, K. Okazaki, A. Murakami, E. Tsuge, M. Abe, H. Aikata, H. Takahashi, S. Ochi, H. Tateno-Mukaidani, C. Yoshizato, K. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Gao, M. Chayama, K.
  • Journal Title: Gut Volume: 62 Issue: 7 Pages: 1055-1061
  • DOI: 10.1136/gutjnl-2012-302600
  • Peer Reviewed
• [Journal Article] Combining molecular targeted drugs to inhibit both cancer cells and activated stromal cells in gastric cancer (2013)
  • Author(s): Onoyama M, Kitadai Y, Tanaka Y, Yuge R, Shinagawa K, Tanaka S, Yasui W, and Chayama K
  • Journal Title: Neoplasia Volume: 15 Issue: 12 Pages: 9-1391
  • DOI: 10.1593/neo.131668
  • Peer Reviewed
• [Journal Article] A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation (2013)
  • Author(s): Nakano Y, Makita N, (32人中31番目) et al
  • Journal Title: PLOS Genet Volume: 9 Issue: 4 Pages: e1003364-e1003364
  • DOI: 10.1371/journal.pgen.1003364
  • NAID: 120006985866
  • Peer Reviewed / Open Access
• [Journal Article] HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study. (2013)
  • Author(s): Miki D, Ochi H, Takahashi A, Hayes CN, Urabe Y, Abe H, Kawaoka T, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Takahashi S, Akuta N, Suzuki F, Ikeda K, Kumada H, Karino Y, Toyota J, Tsunoda T, Kubo M, Kamatani N, Nakamura Y, Chayama K.
  • Journal Title: PLoS One. Volume: 8 Issue: 12 Pages: e84226-e84226
  • DOI: 10.1371/journal.pone.0084226
  • Peer Reviewed
• [Journal Article] Autologous Bone-Marrow Mesenchymal Stem Cell Implantation and Endothelial Function in a Rabbit Ischemic Limb Model (2013)
  • Author(s): Mikami S, Nakashima A, Nakagawa K, Maruhashi T, Iwamoto Y, Kajikawa M, Matsumoto T, Kihara Y, Chayama K, Noma K, Ochi M, Nishimura M, Tsuji K, Kato Y, Goto C, Higashi Y
  • Journal Title: PLOS ONE Volume: 8(7) Issue: 7 Pages: e67739-e67739
  • DOI: 10.1371/journal.pone.0067739
  • NAID: 120006986197
  • Peer Reviewed
• [Journal Article] Identification of a Functional Variant in the MICA Promoter Which Regulates MICA Expression and Increases HCV-Related Hepatocellular Carcinoma Risk. (2013)
  • Author(s): Lo PH, Urabe Y, Kumar V, Tanikawa C, Koike K, Kato N, Miki D, Chayama K, Kubo M, Nakamura Y, Matsuda K.
  • Journal Title: PLoS One. Volume: 8 Issue: 4 Pages: e61279-e61279
  • DOI: 10.1371/journal.pone.0061279
  • Peer Reviewed
• [Journal Article] Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development (2013)
  • Author(s): Lange C M, Miki D, Ochi H, Nischalke H D, Bojunga J, Bibert S, Morikawa K, Gouttenoire J, Cerny A, Dufour J F, Gorgievski-Hrisoho M, Heim M H, Malinverni R, Mullhaupt B, Negro F, Semela D, Kutalik Z, Muller T, Spengler U, Berg T, Chayama K, Moradpour D, Bochud P Y, Hiroshima Liver Study G, and Swiss Hepatitis C C S G
  • Journal Title: PLoS One Volume: 8 Issue: 5 Pages: e64053-e64053
  • DOI: 10.1371/journal.pone.0064053
  • Peer Reviewed
• [Journal Article] Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan. (2013)
  • Author(s): Kitamoto T
  • Journal Title: Human Genetics Volume: 3 Issue: 7 Pages: 1-10
  • DOI: 10.1007/s00439-013-1294-3
  • NAID: 120005474457
  • Peer Reviewed
• [Journal Article] Glycemic variability is an independent predictive factor for development of hepatic fibrosis in nonalcoholic Fatty liver disease. (2013)
  • Author(s): Hashiba M,Ono M,Okamoto N,Saibara T et.al
  • Journal Title: PLoS One Volume: 8(11) Issue: 11 Pages: e76161-e76161
  • DOI: 10.1371/journal.pone.0076161
  • Peer Reviewed
• [Journal Article] Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice with Humanized Livers. (2013)
  • Author(s): Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chavama K, Hijikata M.
  • Journal Title: Gastroenterology Volume: 145 Issue: 3 Pages: 658-667
  • DOI: 10.1053/j.gastro.2013.05.014
  • Peer Reviewed
• [Journal Article] The upper limit of normal serum alanine aminotransferase levels in Japanese subjects. (2013)
  • Author(s): Tanaka K,Ono M,Saibara T et.al
  • Journal Title: Hepatology Research Volume: 23 Issue: 12 Pages: 1196-1207
  • DOI: 10.1111/hepr.12293
  • Peer Reviewed / Open Access
• [Journal Article] Case reports of portal vein thrombosis and bile duct stenosis after stereotactic body radiation therapy for hepatocellular carcinoma. (2013)
  • Author(s): Takahashi S. Kimura T. Kenjo M. Nishibuchi I. Takahashi I. Takeuchi Y. Doi Y. Kaneyasu Y. Murakami Y. Honda Y. Aikata H. Chayama K, and Nagata Y
  • Journal Title: Hepatol Res Volume: 電子書籍 Issue: 10
  • DOI: 10.1111/hepr.12241
  • Peer Reviewed / Open Access
• [Journal Article] Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1. (2013)
  • Author(s): Saibara T, Enomoto N, Kaneko S, Chayama K, Sata M, Imawari M, Onishi S, Okita K.
  • Journal Title: Hepatol Res. Volume: Apr 19 Issue: 4 Pages: 410-419
  • DOI: 10.1111/hepr.12139
  • Peer Reviewed
• [Journal Article] Percutaneous transvenous embolization for portosystemic shunts associated with encephalopathy: Long-term outcomes in 14 patients. (2013)
  • Author(s): Naeshiro N. Kakizawa H. Aikata H. Kan H. Fujino H. Fukuhara T. Kobayashi T. Honda Y. Miyaki D. Kawaoka T. Tsuge M. Hiramatsu A. Imamura M. Kawakami Y. Hyogo H. Ishikawa M. Awai K, and Chayama K
  • Journal Title: Hepatol Res Volume: 電子書籍 Issue: 7 Pages: 740-749
  • DOI: 10.1111/hepr.12181
  • Peer Reviewed / Open Access
• [Journal Article] Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases. (2013)
  • Author(s): Masaki K. Takaki S. Hyogo H. Kobayashi T. Fukuhara T. Naeshiro N. Honda Y. Nakahara T. Ohno A. Miyaki D. Murakami E. Nagaoki Y. Kawaoka T. Tsuge M. Hiraga N. Hiramatsu A. Imamura M. Kawakami Y. Aikata H. Ochi H. Takahashi S. Arihiro K, and Chayama K
  • Journal Title: Hepatol Res Volume: 43 Issue: 11 Pages: 1182-9
  • DOI: 10.1111/hepr.12094
  • Peer Reviewed
• [Journal Article] Changes in mRNA expression of hypothalamic appetite-regulating peptides during different phases of lactation in rats (2013)
  • Author(s): Suzuki Y,Nakahara K, Maruyama K, Okame R, Ensho T, Inoue Y,Murakami N.
  • Journal Title: J Mol Endocrinol Volume: 52 Issue: 1 Pages: 97-109
  • DOI: 10.1016/j.bbrc.2013.10.040
  • Peer Reviewed
• [Journal Article] Dynamic computed tomography appearance of tumor response after stereotactic body radiation therapy for hepatocellular carcinoma: How should we evaluate treatment effects? (2013)
  • Author(s): Kimura T. Takahashi S. Kenjo M. Nishibuchi I. Takahashi I. Takeuchi Y. Doi Y. Kaneyasu Y. Murakami Y. Honda Y. Aikata H. Chayama K, and Nagata Y
  • Journal Title: Hepatol Res Volume: 43 Issue: 7 Pages: 717-27
  • DOI: 10.1111/hepr.12007
  • NAID: 10031194575
  • Peer Reviewed
• [Journal Article] Telaprevir is effective given every 12 hours at 750 mg with peginterferon-alfa-2b and ribavirin to Japanese patients with HCV-1b IL28B rs8099917 TT. (2013)
  • Author(s): Kawakami Y. Suzuki F. Karino Y. Toyota J. Kumada H, and Chayama K
  • Journal Title: Antivir Ther Volume: 5 Issue: 3 Pages: 277-285
  • DOI: 10.3851/imp2706
  • Peer Reviewed
• [Journal Article] Efficacy of probucol for the treatment of non-alcoholic steatohepatitis with dyslipidemia: An open-label pilot study. (2013)
  • Author(s): Ishitobi T. Hyogo H. Tokumo H. Arihiro K, and Chayama K
  • Journal Title: Hepatol Res Volume: 電子書籍 Issue: 4 Pages: 429-435
  • DOI: 10.1111/hepr.12135
  • Peer Reviewed
• [Journal Article] Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C (2013)
  • Author(s): Fujino H. Imamura M. Nagaoki Y. Kawakami Y. Abe H. Hayes C N.et al
  • Journal Title: J Gastroenterol Volume: 電子書籍 Issue: 12 Pages: 1548-1556
  • DOI: 10.1007/s00535-013-0924-9
  • Peer Reviewed / Open Access
• [Journal Article] Response to "treatment guidelines for HCV genotype 1: mono for low, triple for high, and dual for 'middle'?". (2013)
  • Author(s): Chayama K. Hayes C N. Ohishi W, and Kawakami Y
  • Journal Title: J Gastroenterol Volume: 48 Issue: 4 Pages: 557-8
  • DOI: 10.1007/s00535-013-0760-y
  • NAID: 10031169235
  • Peer Reviewed
• [Journal Article] Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B. (2013)
  • Author(s): Arataki K, Hayes CN, Akamatsu S, Akiyama R, Abe H, Tsuge M, Miki D, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami H, Ohishi W, Chayama K.
  • Journal Title: Journal of Medical Virology Volume: 85(5) Issue: 5 Pages: 789-98
  • DOI: 10.1002/jmv.23540
  • Peer Reviewed
• [Journal Article] Dual Oral Therapy with Daclatasvir and Asunaprevir for Patients with HCV Genotype 1b Infection and Limited Treatment Options (2012)
  • Author(s): Suzuki Y, Ikeda K, Suzuki F, Toyota J, Karino Y, Chayama K, et al
  • Journal Title: J Hepatol Volume: 58 Issue: 4 Pages: 655-662
  • DOI: 10.1016/j.jhep.2012.09.037
  • Peer Reviewed
• [Journal Article] Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir (2012)
  • Author(s): Karino Y, Toyota J, Ikeda K, Suzuki F, Chayama K, Kawakami Y, et al
  • Journal Title: J Hepatol Volume: 58 Issue: 4 Pages: 648-645
  • DOI: 10.1016/j.jhep.2012.11.012
  • Peer Reviewed
• [Journal Article] Risk factors for the exacerbation of esophageal varices or portosystemic encephalopathy after sustained virological response with IFN therapy for HCV-related compensated cirrhosis (2012)
  • Author(s): Nagaoki Y, Aikata H, Kobayashi T, Fukuhara T, Masaki K, Tanaka M, et al
  • Journal Title: J Gastroenterol Volume: 48 Issue: 7 Pages: 847-55
  • DOI: 10.1007/s00535-012-0679-8
  • Peer Reviewed
• [Journal Article] Treatment of chronic hepatitis C virus infection in Japan: update on therapy and guidelines (2012)
  • Author(s): Chayama K , Hayes CN, Ohishi W,Kawakami Y
  • Journal Title: J Gastroenterol Volume: 48 Issue: 1 Pages: 1-12
  • DOI: 10.1007/s00535-012-0714-9
  • NAID: 10031145523
  • Peer Reviewed
• [Presentation] New Treatment Paradigms for HCV : The Basics、Asian Pacific Association for the Study of the Liver 2014(APASL 2014) (2014)
  • Author(s): 茶山一彰
  • Organizer: アジア太平洋肝臓病学会議
  • Place of Presentation: ブリスベン(オーストラリア)
  • Year and Date: 2014-03-12
• [Presentation] Optimizing triple therapy, and IFN/RBV free regimens、Asian Pacific Association for the Study of the Liver 2014(APASL 2014) (2014)
  • Author(s): 茶山一彰
  • Organizer: アジア太平洋肝臓病学会議
  • Place of Presentation: ブリスベン(オーストラリア)
  • Year and Date: 2014-03-12
• [Presentation] New Treatment Paradigms for HCV: The Basics (2014)
  • Author(s): 茶山一彰
  • Organizer: Asian Pacific Association for the Study of the Liver 2014（APASL 2014） (アジア太平洋肝臓病学会議)
  • Place of Presentation: ブリスベン(オーストラリア)
• [Presentation] Optimizing triple therapy, and IFN/RBV free regimens (2014)
  • Author(s): 茶山一彰
  • Organizer: Asian Pacific Association for the Study of the Liver 2014（APASL 2014） (アジア太平洋肝臓病学会議)
  • Place of Presentation: ブリスベン(オーストラリア)
• [Presentation] HCV Genotype,Variations Associated with IFN and DAA Resistance (2013)
  • Author(s): 茶山一彰
  • Organizer: Conference Taiwan Association for the Study of the Liver(TASL)2013
  • Place of Presentation: 台湾
  • Year and Date: 2013-12-21
• [Presentation] HCV in Asia IFN-free Regimen for Chronic Hepatitis C in Asia : A Phase IIIstudy in Japanese HCV Genotype 1b Patients (2013)
  • Author(s): 茶山一彰
  • Organizer: Conference Taiwan Association for the Study of the Liver(TASL)2013
  • Place of Presentation: 台湾
  • Year and Date: 2013-12-21
• [Presentation] All-oral Combination of Daclatasvir Plus Asunaprevir in Interferon Ineligible Naive/Intolerant and Nonresponder Japanese Patients Chronically Infected with HCV Genotype 1b : Results from a Phase 3 Trial (2013)
  • Author(s): 茶山一彰
  • Organizer: The 64nd Annual Meeting of American Association for the Study of Liver Diseases 2013(AASLD)
  • Place of Presentation: ワシントン D.C.(U.S.A.)
  • Year and Date: 2013-11-15
• [Presentation] Treatment of Chronic Hepatitis C with First Generation Protease Inhibitors in Asian Population : Telaprevir-Based Triple Therapy in Japanese Population (2013)
  • Author(s): 茶山一彰
  • Organizer: TDDW2013(Taiwan Digestive Disease Week2013)
  • Place of Presentation: 台北(台湾)
  • Year and Date: 2013-10-05
• [Presentation] Studies on Hepatitis Viruses using human hepatocyte chimeric mice (2013)
  • Author(s): 茶山一彰
  • Organizer: 第17回国際肝類洞壁研究シンポジウム(17th ISCHS)
  • Place of Presentation: 大阪
  • Year and Date: 2013-09-25
• [Presentation] C型慢性肝炎の最新治療 (2013)
  • Author(s): 茶山一彰
  • Organizer: 日本内科学会 平成25年度日本内科学会生涯教育講演会Aセッション
  • Place of Presentation: 大阪
• [Presentation] ヒト肝細胞キメラマウスを使用した劇症肝炎モデル (2013)
  • Author(s): 茶山一彰
  • Organizer: 第39回日本急性肝不全研究会
  • Place of Presentation: 東京
• [Presentation] C型肝炎の治療 (2013)
  • Author(s): 茶山一彰
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] C型肝炎の最新の治療 (2013)
  • Author(s): 茶山一彰
  • Organizer: 第67回日本交通医学会総会
  • Place of Presentation: 広島
• [Presentation] C型肝炎に対するDAA製剤の治療効果 (2013)
  • Author(s): 茶山一彰
  • Organizer: 日本消化器病学会中国支部第17回教育講演会
  • Place of Presentation: 岡山
• [Presentation] C型慢性肝炎の最新治療 (2013)
  • Author(s): 茶山一彰
  • Organizer: 日本内科学会 平成25年度日本内科学会生涯教育講演会Aセッション
  • Place of Presentation: 名古屋
• [Presentation] Direct antiviral agent 時代のC型肝炎治療の効果予測因子 (2013)
  • Author(s): 茶山一彰
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Treatment of Chronic Hepatitis C with First Generation Protease Inhibitors in Asian Population:Telaprevir-Based Triple Therapy in Japanese Population (2013)
  • Author(s): 茶山一彰
  • Organizer: TDDW2013(Taiwan Digestive Disease Week2013)
  • Place of Presentation: 台北(台湾）
  • Invited
• [Presentation] B型肝炎治療の最前線 (2013)
  • Author(s): 茶山一彰
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: 東京
• [Presentation] DAAs時代におけるC型慢性肝炎治療戦略と今後の展望 (2013)
  • Author(s): 茶山一彰
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: 東京
• [Presentation] C型慢性肝炎治療の最前線 3剤併用療法の最新のエビデンスと今後の展望 (2013)
  • Author(s): 茶山一彰
  • Organizer: 第17回日本肝臓学会大会
  • Place of Presentation: 東京
• [Presentation] All-oral Combination of Daclatasvir Plus Asunaprevir in Interferon Ineligible Naïve/Intolerant and Nonresponder Japanese Patients Chronically Infected with HCV Genotype 1b:Results from a Phase 3 Trial (2013)
  • Author(s): 茶山一彰
  • Organizer: The 64nd Annual Meeting of American Association for the Study of Liver Diseases 2013(AASLD)
  • Place of Presentation: ワシントンD.C.（U.S.A)
• [Presentation] ヒト肝細胞キメラマウスを用いたHCVの解析と治療 (2013)
  • Author(s): 茶山一彰
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 次世代DAAによる新たなC型肝炎治療 (2013)
  • Author(s): 茶山一彰
  • Organizer: 第40回日本肝臓学会西部会
  • Place of Presentation: 岐阜
• [Presentation] HCV in Asia IFN-free Regimen for Chronic Hepatitis C in Asia: A Phase IIIstudy in Japanese HCV Genotype 1b Patients (2013)
  • Author(s): 茶山一彰
  • Organizer: Conference Taiwan Association for the Study of the Liver(TASL)2013
  • Place of Presentation: 台湾
  • Invited
• [Book] The Lipid、2.エゼチミブ (2013)
  • Author(s): 今村道雄,平賀伸彦,茶山一彰
  • Publisher: メディカルレビュー社
• [Book] 日本消化器病学会雑誌、肝疾患の疾患関連遺伝子-GWASを含めた最近の知見から- (2013)
  • Author(s): 茶山一彰,越智秀典,三木大樹
  • Publisher: 一般財団法人日本消化器病学会
• [Book] 専門医のための消化器病学会、B型l肝炎[治療] (2013)
  • Author(s): 茶山一彰
  • Publisher: 医学書院
• [Book] 肝癌診療 Q&A、"最近は肝癌の背景病態 (B型・C型・NASHなど)に変化が起こっていますか?" (2013)
  • Author(s): 相方浩,兵庫秀幸,茶山一彰
  • Publisher: 中外医学社
• [Book] hepatology Practice第1巻 B型肝炎の診療を極める、III治療編 4.薬物療法の基本方針C薬物療法:合併症の治療 (2013)
  • Author(s): 兵庫秀幸,茶山一彰
  • Publisher: 文光堂
• [Book] hepatology Practice第1巻 B型肝炎の診療を極める、IV .B型肝炎を理解するための基礎研究 4.HBVの感染実験系 (2013)
  • Author(s): 柘植雅貴,茶山一彰
  • Publisher: 文光堂
• [Book] Pharma Medica、C型肝炎インターフェロン・フリー抗ウイルス治療の展望 (2013)
  • Author(s): 川上由育,茶山一彰
  • Publisher: メディカルレビュー社
• [Book] 肝臓、ゲノタイプ3a型のC型急性肝炎の1例―IL28B遺伝子からの考察― (2013)
  • Author(s): 小林知樹,川上由育,平松憲,瀧川英彦,野中裕広,田中未央,苗代典昭,中原隆志,本田洋士,宮木大輔,長沖祐子,河岡友和,高木慎太郎,柘植雅貴,今村道雄,兵庫秀幸,相方浩,高橋祥一,茶山一彰
  • Publisher: 一般社団法人日本肝臓学会
• [Book] 消化器の臨床、B型慢性肝炎 (2013)
  • Author(s): 今村道雄,茶山一彰
  • Publisher: ヴァンメディカル
• [Book] The Lipid、【代謝循環器系薬剤の多面的作用】エゼチミブ (2013)
  • Author(s): 今村道雄,平賀伸彦,茶山一彰
  • Publisher: メディカルレビュー社
• [Book] 消化器内科、【C型慢性肝炎の新たな治療展開】IL28B遺伝子多型からみた3剤併用療法に対する難治性要因 (2013)
  • Author(s): 今村道雄,川上由育,茶山一彰
  • Publisher: 科学評論社
• [Book] The Lipid (2013)
  • Author(s): 今村道雄, 平賀伸彦, 茶山一彰
  • Total Pages: 4
  • Publisher: メディカルレビュー社
• [Book] 日本消化器病学会雑誌 (2013)
  • Author(s): 茶山一彰, 越智秀秀典, 三木大樹
  • Total Pages: 13
  • Publisher: 一般財団法人 日本消化器病学会
• [Book] 専門医のための消化器病学会 (2013)
  • Author(s): 茶山一彰
  • Total Pages: 5
  • Publisher: 医学書院
• [Book] 日本消化器病学会雑誌 (2013)
  • Author(s): 茶山一彰, 越智秀典, 三木大樹
  • Total Pages: 13
  • Publisher: 一般財団法人 日本消化器病学会
• [Book] 肝癌診療Q&A (2013)
  • Author(s): 相方 浩, 兵庫秀幸, 茶山一彰
  • Total Pages: 4
  • Publisher: 中外医学社
• [Book] hepatology Practice 第1巻 B型肝炎の診療を極める (2013)
  • Author(s): 兵庫秀幸, 茶山一彰
  • Total Pages: 4
  • Publisher: 文光堂
• [Book] hepatology Practice 第1巻 B型肝炎の診療を極める (2013)
  • Author(s): 柘植雅貴, 茶山一彰
  • Total Pages: 8
  • Publisher: 文光堂
• [Book] Pharma Medica (2013)
  • Author(s): 川上由育, 茶山一彰
  • Total Pages: 4
  • Publisher: メディカルレビュー社
• [Book] 肝臓 (2013)
  • Author(s): 小林知樹, 川上由育, 平松 憲, 瀧川英彦, 野中裕広, 田中未央, 苗代典昭, 中原隆志, 本田洋士, 宮木大輔, 長沖祐子, 河岡友和, 高木慎太郎, 柘植雅貴, 今村道雄, 兵庫秀幸, 相方 浩, 高橋祥一, 茶山一彰
  • Total Pages: 7
  • Publisher: 一般社団法人日本肝臓学会
• [Book] 消化器の臨床 (2013)
  • Author(s): 今村道雄, 茶山一彰
  • Total Pages: 7
  • Publisher: ヴァンメディカル
• [Book] 消化器内科 (2013)
  • Author(s): 今村道雄, 川上由育, 茶山一彰
  • Total Pages: 4
  • Publisher: 科学評論社
• [Remarks] 広島大学病院消化器・代謝内科ホームページ
  • URL: http://home.hiroshima-u.ac.jp/naika1/research_profile/liver_lab/
• [Remarks] 広島大学病院消化器・代謝内科ホームページ
  • URL: http://home.hiroshima-u.ac.jp/naika1/research_profile/liver_lab/