| Project/Area Number |
25670398
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Masaru 北海道大学, 北海道大学病院, 助教 (10374290)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺線維症 / 慢性閉塞性肺疾患 / 動物モデル |
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| Outline of Final Research Achievements |
In the bleomycin-induced lung fibrosis model, AIM-KO mice had significantly less lung fibrosis than wild-type mice on day 14 after bleomycin administration. Furthermore, in the cigarette smoke-induced emphysema model, AIM-KO mice had significantly less emphysematous change than wild-type mice after 16 weeks of cigarette smoke exposure, and had lower inflammatory gene expression levels after short-term cigarette smoke exposure. These results suggests that AIM plays a role as an aggravating factor in the pathogenesis of inflammatory lung diseases, and that AIM may be one of the potential therapeutic targets or biomarkers for lung diseases.
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