Research Project
Grant-in-Aid for Challenging Exploratory Research
In this study, we aimed the development of evolutional therapy to reconcile both anti-inflammatory/immune suppressive effects and extenuate adverse effects. We applied bionanocapsule-based drug delivery system (DDS) to inhibit immune activation specific for macrophages and selectively at inflammatory sites. We generated fluorescent-conjugated BNC fused with antibody targeting macrophages, and confirmed the BNC distribution on mouse macrophage cell line. Intravenous administration of the BNC into mouse demonstrated fluorescent cells only on injured kidney indicating specific BNC delivery for inflammatory sites. Significant expression of gene enclosed in BNC was not demonstrated, but this study provided fundamental data for the development for leukocyte specific DDS using BNC.
All 2015 2014 2013
All Journal Article (46 results) (of which Peer Reviewed: 46 results, Open Access: 9 results, Acknowledgement Compliant: 1 results) Presentation (114 results)
J Am Soc Nephrol
Volume: inpress Issue: 8 Pages: 1806-1815
10.1681/asn.2013121259
Clinical and Experimental Nephrology
Volume: 印刷中 Issue: 5 Pages: 797-803
10.1007/s10157-014-1064-0
Volume: 印刷中 Issue: 4 Pages: 653-660
10.1007/s10157-014-1054-2
Clin Exp Nephrol
Volume: inpress Issue: 4 Pages: 718-724
10.1007/s10157-014-1046-2
Volume: inpress Issue: 4 Pages: 626-30
10.1007/s10157-014-1038-2
Volume: Epub
PLoS One
Volume: 9(10) Issue: 10 Pages: 110376-110376
10.1371/journal.pone.0110376
J Immunol
Volume: 193(10) Pages: 5129-39
Volume: Epub Issue: 3 Pages: 496-505
10.1007/s10157-014-1022-x
Kidney Int
Volume: 86(1) Issue: 1 Pages: 210-210
10.1038/ki.2014.138
PLoS One.
Volume: 9 Issue: 6 Pages: e100835-e100835
10.1371/journal.pone.0100835
Volume: 86(2) Issue: 2 Pages: 246-50
10.1038/ki.2014.190
Am J Cardiol
Volume: 114(1) Issue: 1 Pages: 42-6
10.1016/j.amjcard.2014.03.058
Volume: 19(1) Issue: 1 Pages: 114-24
10.1007/s10157-014-0965-2
Nephrol Dial Transplant
Volume: 29(8) Issue: 8 Pages: 1546-53
10.1093/ndt/gfu020
Int J Cardiol
Volume: 172(2) Issue: 2 Pages: e293-e296
10.1016/j.ijcard.2013.12.193
Trials
Volume: 16 Issue: 1 Pages: 15-26
10.1186/1745-6215-15-26
Volume: 85 Issue: 3 Pages: 641-8
10.1038/ki.2013.544
J Rheumatol.
Volume: 41(2) Issue: 2 Pages: 325-33
10.3899/jrheum.130602
Volume: 18(5) Issue: 5 Pages: 784-94
10.1007/s10157-013-0925-2
Clin Exp Nephrol.
Volume: 18 Issue: 5 Pages: 746-54
10.1007/s10157-013-0916-3
Volume: 18(5) Issue: 5 Pages: 737-45
10.1007/s10157-013-0915-4
Volume: 18(3) Issue: 3 Pages: 475-80
10.1007/s10157-013-0848-y
Volume: 18 Issue: 3 Pages: 481-486
10.1007/s10157-013-0849-x
40019847882
Volume: 18(3) Issue: 3 Pages: 469-74
10.1007/s10157-013-0841-5
J Cardiol.
Volume: S0914-5087(13) Issue: 1 Pages: 352-3
10.1016/j.jjcc.2013.10.018
Cytotherapy.
Volume: 16(3) Issue: 3 Pages: 357-68
10.1016/j.jcyt.2013.10.011
Clin J Am Soc Nephrol.
Volume: 8(5) Issue: 5 Pages: 721-30
10.2215/cjn.06470612
Volume: 17(2) Issue: 2 Pages: 155-73
10.1007/s10157-012-0746-8
10031169463
Volume: 17(5) Issue: 5 Pages: 730-42
10.1007/s10157-012-0758-4
Am J Pathol
Volume: 182(2) Issue: 2 Pages: 410-419
10.1016/j.ajpath.2012.10.016
Am J Kidney Dis
Volume: 61(2) Issue: 2 Pages: 254-61
10.1053/j.ajkd.2012.09.007
J Am Soc Nephrol.
Volume: 24(4) Issue: 4 Pages: 587-603
10.1681/asn.2012030264
Volume: 17(6) Issue: 6 Pages: 827-33
10.1007/s10157-013-0779-7
Am J Physiol Renal Physiol.
Volume: 305(11) Issue: 11 Pages: 1603-1616
10.1152/ajprenal.00681.2012
Intern Med.
Volume: 52(11) Pages: 1177-81
130003365636
Nephrol Dial Transplant.
Volume: 29(2) Issue: 2 Pages: 228-31
10.1093/ndt/gft463