• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

DNA vaccine for diabetes and dyslipidemia

Research Project

Project/Area Number 25670433
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionOsaka University

Principal Investigator

MORISHITA Ryuichi  大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (40291439)

Co-Investigator(Kenkyū-buntansha) NAKAGAMI Hironori  大阪大学, 大学院医学系研究科, 教授 (20325369)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsワクチン / 糖尿病 / 脂質異常症
Outline of Final Research Achievements

We developed a dipeptidyl peptidase 4 (DPP4)-targeted immune therapy for the prevention and treatment of type 2 diabetes mellitus and a Lp(a)-targeted immune therapy for the treatment of high Lp(a) patients. Immunization with the DPP4 vaccine in C57BL/6J mice successfully increased DPP4 titer and inhibited plasma DPP4 activity. Moreover, this elevated titer was sustained for 3 month. In mice fed a high-fat diet, DPP4 vaccination resulted in improved postprandial glucose excursions and insulin sensitivity and, in the diabetic KK-Ay and db/db mice strains, DPP4 vaccination significantly reduced glucose excursions and increased both plasma insulin and pancreatic insulin content.Thus, this DPP4 vaccine may provide a therapeutic alternative for patients with diabetes.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Therapeutic vaccine against DPP4 improves glucose metabolism in mice.2014

    • Author(s)
      Pang Z, Nakagami H, Osako MK, Koriyama H, Nakagami F, Tomioka H, Shimamura M, Kurinami H, Takami Y, Morishita R, Rakugi H.
    • Journal Title

      Proc Natl Acad Sci U S A. 2014 ;111(13):E1256-63.

      Volume: 111(13)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of novel DNA vaccine for VEGF in murine cancer model.2013

    • Author(s)
      Kyutoku M
    • Journal Title

      Sci Rep.

      Volume: 3 Issue: 1 Pages: 3380-3380

    • DOI

      10.1038/srep03380

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Therapeutic vaccine against DPP4 improves glucose metabolism in mice2014

    • Author(s)
      中神 啓徳
    • Organizer
      第14回日本抗加齢医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-07
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi