DNA vaccine for diabetes and dyslipidemia
Project/Area Number |
25670433
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Osaka University |
Principal Investigator |
MORISHITA Ryuichi 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (40291439)
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Co-Investigator(Kenkyū-buntansha) |
NAKAGAMI Hironori 大阪大学, 大学院医学系研究科, 教授 (20325369)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | ワクチン / 糖尿病 / 脂質異常症 |
Outline of Final Research Achievements |
We developed a dipeptidyl peptidase 4 (DPP4)-targeted immune therapy for the prevention and treatment of type 2 diabetes mellitus and a Lp(a)-targeted immune therapy for the treatment of high Lp(a) patients. Immunization with the DPP4 vaccine in C57BL/6J mice successfully increased DPP4 titer and inhibited plasma DPP4 activity. Moreover, this elevated titer was sustained for 3 month. In mice fed a high-fat diet, DPP4 vaccination resulted in improved postprandial glucose excursions and insulin sensitivity and, in the diabetic KK-Ay and db/db mice strains, DPP4 vaccination significantly reduced glucose excursions and increased both plasma insulin and pancreatic insulin content.Thus, this DPP4 vaccine may provide a therapeutic alternative for patients with diabetes.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Therapeutic vaccine against DPP4 improves glucose metabolism in mice.2014
Author(s)
Pang Z, Nakagami H, Osako MK, Koriyama H, Nakagami F, Tomioka H, Shimamura M, Kurinami H, Takami Y, Morishita R, Rakugi H.
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Journal Title
Proc Natl Acad Sci U S A. 2014 ;111(13):E1256-63.
Volume: 111(13)
Related Report
Peer Reviewed / Open Access
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