Elucidation of metabolic shift of skeletal muscle during aging and invention of new therapies for sarcopenia
Project/Area Number |
25670437
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
SHIGEMOTO Kazuhiro 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (40284400)
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Co-Investigator(Kenkyū-buntansha) |
久保 幸穂 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), その他部局等, その他 (00280769)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | サルコペニア / 筋萎縮 / 動物モデル / 代謝 / 筋線維 / 代謝変化 / 筋線維タイプ / 骨格筋線維 |
Outline of Final Research Achievements |
Sarcopenia impairs activity of daily living of aged people. For the early prevention or treatment of such conditions, it is required to understand the pathogenesis and invent effective therapies. In this study, we will elucidate the metabolic changes in skeletal muscle during aging and establish the new technologies for developing innovative preventive and therapeutic methods by remodleing the metabolism.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Layer-specific dilation of penetrating arteries induced by stimulation of the nucleus basalis of Meynert in the mouse frontal cortex.2013
Author(s)
Hotta, H., Masamoto,K., Uchida,S.,Sekiguchi,Y., Takuwa,H., Kawaguchi,H., Shigemoto,K., Sudo,R., Tanishita,K., Ito,H. and Kanno,I.
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Journal Title
J Cereb Blood Flow Metab.
Volume: 9
Issue: 9
Pages: 1440-7
DOI
Related Report
Peer Reviewed
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[Presentation] A murine model of myasthenia gravis with MuSK antibodies; effect of genetic background.2013
Author(s)
Mori, S., Kubo, S., Akiyoshi, T., Yamada, S., Miyazaki, T., Hotta, H., Desaki, J., Kishi, M., Konishi, T., Maruyama, N. and Shigemoto, K.
Organizer
Myasthenia 2013
Place of Presentation
Paris,France
Related Report
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