A novel mechanism of posttransplant female infertiliy
Project/Area Number |
25670443
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Hokkaido University |
Principal Investigator |
TESHIMA TAKANORI 北海道大学, 医学(系)研究科(研究院), 教授 (40284096)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 造血幹細胞移植 / GVHD / 卵巣 / 不妊 / 免疫抑制剤 |
Outline of Final Research Achievements |
Infertility associated with ovarian failure is a serious late complication for female survivors of allogeneic hematopoietic stem cell transplantation (allo-SCT). We have addressed whether GVHD could impact female fertility in murine models of allo-SCT. Our results demonstrate for the first time that GVHD induces infertility by targeting the granulosa cells in the ovaries and GVHD prevention could preserve ovarian functions. These results have important clinical implications in young female transplant recipients with nonmalignant diseases, where minimally toxic chemotherapies prior to SCT and conditioning regimen were used.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning.2014
Author(s)
Koyama M, Hashimoto D, Nagafuji K, Eto T, Ohno Y, Aoyama K, Iwasaki H, Miyamoto T, Hill GR, Akashi K, Teshima T.
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Journal Title
Bone Marrow Transplant.
Volume: 2014
Issue: 1
Pages: 110-115
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mammalian target of rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease.2014
Author(s)
Sugiyama H, Maeda Y, Nishimori H, Yamasuji Y, Matsuoka K, Fjii N, Kondo E, Shinagawa K, Takeuchi K, Teshima T, and Tanimoto M
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Journal Title
Biol Blood Marrow Transplant.
Volume: 20
Issue: 2
Pages: 183-91
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bone Marrow Graft-versus-Host Disease: Evaluation of Its Clinical Impact on Disrupted Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation2014
Author(s)
Souichi Shiratori, Mizuha Kosugi-Kanaya, Satoshi Ueha, Junichi Sugita1, Akio Shigematsu, Takeshi Kondo, Daigo Hashimoto, Katsuya Fujimoto, Tomoyuki Endo, Mitsufumi Nishio, Satoshi Hashino, Yoshihiro Matsuno, Kouji Matsushima, Junji Tanaka, Masahiro Imamura, Takanori Teshima
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Journal Title
Biol Blood Marrow Transplant
Volume: 20
Issue: 4
Pages: 495-500
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Stenotrophomonas maltophilia infection during allogeneic hematopoietic stem cell transplantation: a single-center experience2014
Author(s)
Shiratori S, Wakasa K, Okada K, Sugita J, Akizawa K, Shigematsu A, Hashimoto D, Fujimoto K, Endo T, Kondo T, Shimizu C, Hashino S, Teshima T
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Journal Title
Clin Transplant
Volume: 28(6)
Issue: 6
Pages: 656-661
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] High Level of Serum Soluble Interleukin-2 Receptor at Transplantation Predicts Poor Outcome of Allogeneic Stem Cell Transplantation for Adult T Cell Leukemia.2014
Author(s)
Shigematsu A, Kobayashi N, Yasui H, Shindo M, Kakinoki Y, Koda K, Iyama S, Kuroda H, Tsutsumi Y, Imamura M, Teshima T.
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Journal Title
Biol Blood Marrow Transplant
Volume: -
Issue: 6
Pages: 801-805
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Use of Oral Beclomethasone Dipropionate in the Treatment of Gastrointestinal Graft-versus-host Disease: The Experience of the Fukuoka Blood and Marrow Transplantation (BMT) Group2014
Author(s)
Takashima S, Eto T, Shiratsuchi M, Hidaka M, Mori Y, Kato K, Kamezaki K, Oku S, Henzan H, Takase K, Matsushima T, Takenaka K, Iwasaki H, Miyamoto T, Akashi K, Teshima T
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Journal Title
Internal Medicine
Volume: 53
Issue: 12
Pages: 1315-1320
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome.2014
Author(s)
Shiratori S, Fujimoto K, Nishimura M, Hatanaka KC, Kosugi-Kanaya M, Okada K, Sugita J, Shigematsu A, Hashimoto D, Endo T, Kondo T, Abe R, Hashino S, Matsuno Y, Shimizu H, Teshima T.
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Journal Title
Hematol Oncol
Volume: Epub Ahead of Print
Issue: 1
Pages: 9-16
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hepatitis B virus (HBV) reverse seroconversion (RS) can be prevented even in non-responders to hepatitis B vaccine after allogeneic stem cell transplantation: long-term analysis of intervention in RS with vaccine for patients with previous HBV infection2014
Author(s)
Takahata M, Hashino S, Onozawa M, Shigematsu A, Sugita J, Fujimoto K, Endo T, Kondo T, Tanaka J, Imamura M, Teshima T
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Journal Title
Transpl Infect Dis
Volume: 16(5)
Issue: 5
Pages: 797-801
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Evaluation of the feasibility and efficacy of autologous stem cell transplantation in elderly patients with multiple myeloma.2013
Author(s)
Muta T, Miyamoto T, Fujisaki T, Ohno Y, Kamimura T, Kato K, Takenaka K, Iwasaki H, Eto T, Takamatsu Y, Teshima T, Akashi K
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Journal Title
Intern Med
Volume: 52(1)
Pages: 63-70
NAID
Related Report
Peer Reviewed
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[Journal Article] Decrease in Venous Irritation by Adjusting the Concentration of Injected Bendamustine2013
Author(s)
Watanabe H, Ikesue H, Tsujikawa T, Nagata K, Uchida M, Suetsugu K, Egashira N, Muta T, Kato K, Takenaka K, Ohga S, Matsushima T, Shiratsuchi M, Miyamoto T, Teshima T, Akashi K, Oishi R
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 36
Issue: 4
Pages: 574-578
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed
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[Journal Article] Diagnosis and evaluation of intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation following reduced-intensity and myeloablative conditioning regimens2013
Author(s)
Yamasaki S, Miyagi-Maeshima A, Kakugawa Y, Matsuno Y, Ohara-Waki F, Fuji S, Morita-Hoshi Y, Mori M, Kim S, Mori S, Fukuda T, Tanosaki R, Shimono T, Tobinai K, Saito D, Takaue Y, Teshima T, Heike Y
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Journal Title
Int J Hematol
Volume: 97(3)
Issue: 3
Pages: 421-426
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Autologous peripheral blood stem cell transplantation with granulocyte colony-stimulating factor combined conditioning regimen as a postremission therapy for acute myelogenous leukemia in first complete remission2013
Author(s)
Eto T, Takase K, Miyamoto T, Ohno Y, Kamimura T, Nagafuji K, Takamatsu Y, Teshima T, Gondo H, Taniguchi S, Akashi K, Harada M
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Journal Title
Int J Hematol
Volume: 98
Issue: 2
Pages: 186-196
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Unrelated allogeneic bone marrow-derived mesenchymal stem cells for steroid-refractory acute graft-versus-host disease: a phase I/II study.2013
Author(s)
Muroi K, Miyamura K, Ohashi K, Murata M, Eto T, Kobayashi N, Taniguchi S, Imamura M, Ando K, Kato S, Mori T, Teshima T, Mori M, Ozawa K.
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Journal Title
Int J Hematol.
Volume: 98
Issue: 2
Pages: 206-213
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Combination of high-dose melphalan and bortezomib as conditioning regimen for autologous peripheral blood stem cell transplantation in multiple myeloma.2013
Author(s)
Miyamoto T, Yoshimoto G, Kamimura T, Muta T, Takashima S, Ito Y, Shiratsuchi M, Choi I, Kato K, Takenaka K, Iwasaki H, Takamatsu Y, Teshima T, Akashi K.
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Journal Title
Int J Hematol
Volume: 98
Issue: 3
Pages: 337-345
DOI
Related Report
Peer Reviewed
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[Journal Article] Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration2013
Author(s)
Aoyama K, Saha A, Tolar J, Riddle MJ, Veenstra RG, Taylor PA, Blomhoff R, Panoskaltsis-Mortari A, Klebanoff CA, Socie G, Munn DH, Murphy WJ, Serody JS, Fulton L, Teshima T, Chandraratna RA, Dmitrovsky E, Guo Y, Noelle RJ, Blazar BR
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Journal Title
Blood
Volume: 122(12)
Issue: 12
Pages: 2125-2134
DOI
Related Report
Peer Reviewed
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[Journal Article] Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease.2013
Author(s)
Eriguchi Y, Uryu H, Nakamura K, Shimoji S, Takashima S, Iwasaki H, Miyamoto T, Shimono N, Hashimoto D, Akashi K, Ayabe T, Teshima T.
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Journal Title
Biol Blood Marrow Transplant
Volume: 19
Issue: 10
Pages: 1525-1529
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Clinical outcomes of allogeneic stem cell transplantation for relapsed or refractory follicular lymphoma: a retrospective analysis by the Fukuoka Blood and Marrow Transplantation Group.2013
Author(s)
107 Ito Y, Miyamoto T, Kamimura T, Takase K, Henzan H, Sugio Y, Kato K, Ohno Y, Eto T, Teshima T, Akashi K
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Journal Title
Int J Hematol
Volume: 98
Issue: 4
Pages: 463-471
DOI
Related Report
Peer Reviewed
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[Presentation] 同種造血幹細胞移植後の不妊2014
Author(s)
下地 園子, 加藤 光次, 辻極 秀次, 江里口 芳裕, 瓜生 英尚, 髙嶋 秀一郎, 橋本 大吾, 宮本 敏浩, 岩崎 浩己, 赤司 浩一, 豊嶋 崇徳
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪国際会議場(大阪府・大阪市)
Year and Date
2014-10-31 – 2014-11-02
Related Report
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