| Project/Area Number |
25670460
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kagawa University (2015)
Kyoto University (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHAMA Yasushi 京都大学, 大学院薬学研究科, 教授 (30439244)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 樹状細胞 / I型インターフェロン / 小胞輸送 / キナーゼ |
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| Outline of Final Research Achievements |
Plasmacytoid dendritic cells (pDC) produce a vast amount of IFN-alpha by recognizing exogenous DNA through TLR9, and provoke autoimmune and inflammatory disorders. A multi-kinase inhibitor dasatinib suppresses the IFN-alpha production by pDC. To identify the responsible kinases and their substrates, we used various kinase inhibitors and mRNA knockdown, and selected 3 kinases as candidate kinases.
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