Screening of Flu Alarmin biomarkers of severe influenza virus infection and their confirmation in animal model
| Project/Area Number |
25670466
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KIDO Hiroshi 徳島大学, 疾患酵素学研究センター, 特任教授 (50144978)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 重症度 / ATP / 乳酸 / リアルタイム・バイオマーカー / エネルギー代謝 / 代謝障害 / 予後判定 / サイトカイン / インフルエンザ / 多臓器不全 / 重症化 / バイオマーカー / 血管透過性亢進 / Flu Alarmin |
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| Outline of Final Research Achievements |
Influenza A virus (IAV) causes significant morbidity and mortality. We found that energy metabolic disorder is a principal cause of multiorgan failure in severe influenza virus infection. Among the analyzed biomarkers in the blood, lactate/ATP ratio is a useful and prognostic biomarker of the disease severity in animal model and clinical data. In addition, we established SmartAmp system for detection of thermolabile carnitine palmitoyltransferase 2 SNPs as risk factors for influenza associated encephalopathy in the infected young children.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Anti-influenza activity of C60 fullerene derivatives.2013
Author(s)
Shoji M., Takahashi E., Hatakeyama D., IwaiY.,MoritaY.,Shirayama R.,Echigo N., Kido H., Nakamura S., Mashino T., Okutani T., Kuzuhara T.
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Journal Title
PLoS ONE
Volume: (in press)
Issue: 6
Pages: e66337-e66337
DOI
Related Report
Peer Reviewed
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