| Project/Area Number |
25670488
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
Nagata Koh-ichi 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 部長 (50252143)
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| Co-Investigator(Kenkyū-buntansha) |
山形 崇倫 自治医科大学, 医学部, 教授 (00239857)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自閉性障害 / 神経細胞 / 大脳皮質構築 / 自閉症 / 大脳皮質形成 / NR1D1 / 大脳皮質 / RBFOX1 / Migfilin / 自閉性疾患 / 神経細胞移動 / 発達障害 |
|---|
| Outline of Final Research Achievements |
While many different biological causes have been implicated in the etiologies of neurodevelopmental disorders such as autism-spectrum disorder (ASD), genetic factors are considered to be the most important. Thus, it is essential to clarify the pathophysiological significance of respective disease-related genes in brain development. To address this issue, we performed genetic analyses of ASD patients and found a single amino acid mutation in a patient. We then carried out a comprehensive analyses with in utero electroporation including cortical neuron migration, axon elongation, dendrite developmentand live-imaging. Consequently we found abnormal phenotypes in the above analyses.
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