Project/Area Number |
25670496
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Dermatology
|
Research Institution | Asahikawa Medical College |
Principal Investigator |
TSUJI Hitomi 旭川医科大学, 医学部, 研究生 (50400106)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
Keywords | 尋常性乾癬 / 脂肪細胞 / 肥満 / アディポサイトカイン / SLURP-2 / 肥大化 |
Outline of Final Research Achievements |
Overexpression of SLURP-2 (secreted Ly-6/uPar related protein-2), which is up-regulated in psoriatic lesion, enhanced the differentiation, enlargement and proliferation of mature adipocytes. In addition, it down-regulated the expression of adiponectin and up-regulated that of IL-6 and visfatin. The result of co-culture of SLURP-2-transfected-adipocytes with immunocytes showed the increase of IL-17 and IL-1β. These findings suggest that SLURP-2 may involve in refractory psoriasis associated with obesity.
|