| Project/Area Number |
25670496
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
TSUJI Hitomi 旭川医科大学, 医学部, 研究生 (50400106)
|
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 尋常性乾癬 / 脂肪細胞 / 肥満 / アディポサイトカイン / SLURP-2 / 肥大化 |
|---|
| Outline of Final Research Achievements |
Overexpression of SLURP-2 (secreted Ly-6/uPar related protein-2), which is up-regulated in psoriatic lesion, enhanced the differentiation, enlargement and proliferation of mature adipocytes. In addition, it down-regulated the expression of adiponectin and up-regulated that of IL-6 and visfatin. The result of co-culture of SLURP-2-transfected-adipocytes with immunocytes showed the increase of IL-17 and IL-1β. These findings suggest that SLURP-2 may involve in refractory psoriasis associated with obesity.
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