| Project/Area Number |
25670516
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
OZAKI Norio 名古屋大学, 医学(系)研究科(研究院), 教授 (40281480)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAI Hiroo 京都大学, 霊長類研究所, 准教授 (60314176)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ニホンザル / CNV / ゲノムコピー数変異 / 霊長類 / 精神疾患 / モデル動物 |
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| Outline of Final Research Achievements |
Recent genomic studies of psychiatric disorders have identified rare copy number variants (CNVs) with large effect size. In order to discover primate model for psychiatric disorders, we have performed genome-wide CNV screening in Japanese macaque. As a result, we detected CNVs overlapping neurodevelopmental genes including GRM5, NGF, BDNF, and ADORA2A. In particular, a duplication of ADORA2A region was previously implicated in psychiatric and neurodevelopmental disorders. Abnormal behaviors were not identified in one Japanese macaque with ADORA2A duplication, and a detailed phenotype analysis will be necessary in the future. In conclusion, we discovered candidates of primate model for psychiatric disorders, confirming the usefulness of CNV analyses for Japanese macaque.
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