An Attempt to Establish the Technology for Estimating Real Irradiated Dose of Particle Therapy in a Living Body

• Project/Area Number: 25670527
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: KATOH Hiroyuki 群馬大学, 重粒子線医学推進機構, 助教 (30334121)
• Co-Investigator(Kenkyū-buntansha): SHIRAI Katsuyuki 群馬大学, 医学(系)研究科(研究院), 講師 (10400748) ; KAWAMURA Hidemasa 群馬大学, 医学(系)研究科(研究院), 講師 (80431716) ; OKAMOTO Masahiko 群馬大学, 医学部附属病院, 講師 (10451725)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 放射線治療 / 粒子線治療 / 線量分布 / QA/QC / 重粒子線治療 / 自己放射化PET

Outline of Final Research Achievements

In our study, we showed that MRI(T2WI) signal intensity of area irradiated higher dose was changed higher intensity one year after carbon-ion radiotherapy for prostate cancer. We measured iso-center dose profiles of estimating dose in treatment planning system and iso-center signal intensity profiles of MRI(T2WI) scanned one year after irradiation. We analyzed both of profiles and we got the relationship among them. This study shows the possibility to develop the technology for estimating a real irradiated dose of particle therapy in a living body without invasive.

Research Products

• [Journal Article] Changes in Rectal Dose Due to Alterations in Beam Angles for Setup Uncertainty and Range Uncertainty in Carbon-Ion Radiotherapy for Prostate Cancer (2016)
  • Author(s): Yoshiki Kubota, Hidemasa Kawamura, Makoto Sakai, Ryou Tsumuraya, Mutsumi Tashiro, Ken Yusa, Nobuteru Kubo, Hiro Sato, Masahiro Kawahara, Hiroyuki Katoh, Tatsuaki Kanai, Tatsuya Ohno, Takashi Nakano
  • Journal Title: PLOS ONE Volume: April Issue: 4 Pages: 1-11
  • DOI: 10.1371/journal.pone.0153894
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Incidence, risk factors, and dose-volume relationship of radiation-induced rib fracture after carbon ion radiotherapy for lung cancer (2016)
  • Author(s): Abe T, Shirai K, Saitoh J, Ebara T, Shimada H, Tashiro M, Okano N, Ohno T, Nakano T
  • Journal Title: Acta Oncol. Volume: 55 Issue: 2 Pages: 163-166
  • DOI: 10.3109/0284186x.2015.1088169
  • Peer Reviewed
• [Journal Article] 重粒子線単独治療を行った前立腺癌症例における治療後1年間のPSA値の変化 (2014)
  • Author(s): 加藤弘之、河村英将、村田和俊、神沼拓也、石川仁、松井博、伊藤一人、鈴木和浩、大野達也、中野隆史
  • Journal Title: 泌尿器外科 Volume: Vol.27 Pages: 1361-1363
  • Peer Reviewed
• [Journal Article] 重粒子線治療 (2014)
  • Author(s): 加藤弘之、大野達也
  • Journal Title: 臨床腫瘍プラクティス Volume: Vol.10 Pages: 312-315
  • Peer Reviewed
• [Presentation] Carbon-ion Beam Range Verification Using the Muscular Intensity Changes of the Magnetic Resonance Image (2015)
  • Author(s): Masahiro Kawahara, Hiroyuki Katoh, Hidemasa Kawamura, Nobuteru Kubo, Hiro Tatsuaki Kanai, Takashi Nakano
  • Organizer: Particle Therapy Co-Operative Group 54th Annual Conference
  • Place of Presentation: San Diego, United States
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Presentation] Comparison of dose distributions between carbon ion beam and IMRT in locally advanced pancreas cancer (2015)
  • Author(s): Mashiko Okamoto, Hiroki Kiyohara, Kyohei Fukata, Naoko Okano, Keitaro Hirai, Kenichiro Araki, Izumi Takeyoshi, Tatsuya Ohno, Takashi Nakano
  • Organizer: Particle Therapy Co-Operative Group 54th Annual Conference
  • Place of Presentation: San Diego, United States
  • Year and Date: 2015-05-18
  • Int'l Joint Research
• [Remarks] EQD Calculator
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• [Remarks] TDF Calculator
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