| Project/Area Number |
25670533
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
Hatazawa Jun 大阪大学, 医学系研究科, 教授 (70198745)
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| Co-Investigator(Kenkyū-buntansha) |
渡部 直史 大阪大学, 医学系研究科, 招へい教員 (90648932)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | アセチルコリンエステラーゼ / アセチルコリン / PET / ドネペジル / 膵 |
|---|
| Outline of Final Research Achievements |
Acetylcholine is a neurotransmitter contributing to control of pancreatic excretion and insulin secretion from beta cells. We tested C-11 labeled acetylcholine esterase inhibitor Donepezil (DNP) as a biomarker of pancreatic function in rats and normal humans. In rats, high accumulation of DNP was found in intestine, pancreas, and adrenal gland where acetylcholine esterase concentration was high in the autopsied tissue, indicating C-11 DNP is a marker of acetlycholinergic function. In humans, high accumulation of C-11 DNP was found in myocardium, pancreas, and intestine, but not in adrenal gland. The current study revealed a species difference in controlling myocardium and adrenal gland function by acetylcholine between rat and humans.
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