Simultaneous imaging of multiple bio-functions by EPR imaging method

Research Project

Project/Area Number	25670537
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Sapporo Medical University
Principal Investigator	FUJII Hirotada 札幌医科大学, 医療人育成センター, 教授 (70209013)
Co-Investigator(Renkei-kenkyūsha)	AKABA Hideo 大阪大学大学院, 基礎工学研究科, 准教授 (00552077)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	視覚化 / イメージング / EPR / ESR / ストレス
Outline of Final Research Achievements	Electron Paramagnetic Resonance Imaing (EPRI) combinded with nitroxide imaging probes is known to be a powerful non-invasive method for visualizating the redox status in vivo. Recently we have improved teh conventional L-band EPR imager using the rapid-scan technique, and it becomes possible to obtain three-dimensional EPR images of small rodents. Using this improved EPR imager, simultaneous imaging of multiple bio-functions, such as redox status, oxygen concnetration, and pH, was carried out non-invasively.