Transcriptome analysis of leukocytes from sarcoma patients for helpful biomarkers
| Project/Area Number |
25670544
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
SAITO Toshiyuki 国立研究開発法人放射線医学総合研究所, 重粒子医科学センター, 主任研究員 (90205667)
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| Co-Investigator(Kenkyū-buntansha) |
KOBASHI Gen 獨協医科大学, 医学部, 教授 (60270782)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | がん / 骨軟部腫瘍 / 骨肉腫 / 脊索腫 / 遺伝子発現 / 血液 / バイオマーカー / トランスクリプトーム |
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| Outline of Final Research Achievements |
To obtain novel biomarkers helpful for diagnosis of sarcomas or musculoskeletal tumors, leukocytes from 6 cases and 4 controls were subjected to a high accuracy large-scale gene expression analysis of 8,919 mRNAs revealed difference of transcriptome between the cases and controls. It is suggested that studies focusing on differentially-expressed transcripts might discriminate cases from controls with high accuracy in the future.
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Report
(4 results)
Research Products
(1 results)
