| Project/Area Number |
25670557
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
YAMADA Kazuhiko 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 教授 (40241103)
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| Co-Investigator(Kenkyū-buntansha) |
SAHARA Hisashi 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 准教授 (90452333)
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| Research Collaborator |
KOBAYASHI Atsushi
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 移植・再生医療 / 前臨床実験 / 高圧 / 臓器保存 / 腎移植 / 心移植 / ミニブタ / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
To extend organ preservation time, we attempted to establish a new preservation method in a stable unfrozen state below its freezing point by pressurizing the solution. To clarify the effects of high pressure on the kidney and heart, we performed kidney/heart transplantation in CLAWN miniature swine using the grafts preserved under high pressure (kidney: 60-120 MPa; heart: 30-60 MPa). Both kidney and heart grafts preserved under pressurized, subzero non-frozen condition had sufficient function after orthotopic kidney/heterotopic heart transplantation indicating that this method could be the novel strategy to extend organ preservation time.
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