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Development of cancer specific Gd neutron capture therapy using membrane fusion protein & nuclear locarization signal

Research Project

Project/Area Number 25670571
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

Yanagie Hironobu  東京大学, 工学(系)研究科(研究院), 研究員 (30212278)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Hiroyuki  東京大学, 大学院工学系研究科(工学部), 教授 (70216753)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsガドリニウム化合物 / 中性子捕捉療法 / Drug Delivery System / ナノミセル / ポリエチレングリコール / リン酸カルシウム / ポリエチレンイミン / 膜融合ペプチド / ガドニウム化合物 / Drug delivery System / JTS-1
Outline of Final Research Achievements

Cancer cell cytotoxicity was obtained by gamma ray and auger electron derived the reaction between Gadolinium(Gd) and thermal neutron in Gd neutron capture therapy(NCT). It is necessary to accumulate the Gd atoms in the cancer cell, especially, in nucleus, for selective damage to cancer cells without the affect to neighbor normal tissues, so it is important to develop the Drug Delivery System.
We prepared Gadoteridol entrapped poly-cationized-calcium phosphate nano micelle coating with polyethylene glycol (Ca-P nano micelle). Gd concentration in tumour was keeping higher compare to original Gd solution until 24hrs after intraveneous injection(IV). After IV injection of Gd Ca-P nano micelle, 50 % of tumour growth suppression was shown in Colon 26 mouse subcutaneous tumour model with thermal neutron irradiation at Kyoto University Research Reactor Institute. We hope to develop the Gd NCT as selective novel cancer therapy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (8 results) (of which Invited: 2 results)

  • [Journal Article] In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent2016

    • Author(s)
      Novriana Dewi, Peng Mi, Hironobu Yanagie, Yuriko Sakurai, Yasuyuki Morishita, Masashi Yanagawa, Takayuki Nakagawa, Atsuko Shinohara, Takehisa Matsukawa, Kazuhito Yokoyama, Horacio Cabral, Minoru Suzuki, Yoshinori Sakurai, Hiroki Tanaka, Koji Ono, Nobuhiro Nishiyama, Kazunori Kataoka, Hiroyuki Takahashi
    • Journal Title

      Journal of Cancer Research and Clinical Oncology

      Volume: 142 Issue: 4 Pages: 767-775

    • DOI

      10.1007/s00432-015-2085-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tumor growth suppression by gadolinium-neutron capture therapy using gadolinium-entrapped liposome as gadolinium delivery agen2013

    • Author(s)
      N. Dewi, H. Yanagie, H. Zhu, K. Demachi, A. Shinohara, K. Yokoyama, M. Sekino, Y. Sakurai, Y. Morishita, N. Iyomotog, T. Nagasaki, Y. Horiguchi, Y. Nagasaki, J. Nakajima, K. Ono, K.Kakimi, H.Takahashi
    • Journal Title

      Biomed. Biopharmacother.

      Volume: 67 Issue: 6 Pages: 451-457

    • DOI

      10.1016/j.biopha.2012.11.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Tumour growth suppression by gadolinium capture therapy with multipleinjections of Gd-DTPA-containing calcium phosphate-based nanoparticles2015

    • Author(s)
      Dewi N, Yanagie H,Takahashi H,et al
    • Organizer
      8th Young Researchers’ BNCT Meeting
    • Place of Presentation
      Pavia,Italy
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] In vivo evaluation of gadolinium neutron capture therapy effectivity with multiple injections of calcium phosphate-based nanoparticles incorporating Gd-DTPA2015

    • Author(s)
      Dewi N, Yanagie H,Takahashi H,et al
    • Organizer
      12th Congress on Neutron Capture Therapy
    • Place of Presentation
      Kobe Gakuin University,Kobe,JAPAN
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tumor growth suppression by neutron capture therapy using Gd-DTPA-incorporated calcium phosphate nanoparticles as gadolinium drug agent2014

    • Author(s)
      Novriana Dewi, Yanagie H, Takahashi H.,et al.
    • Organizer
      第11回日本中性子捕捉療法学会
    • Place of Presentation
      大阪大学 大阪
    • Year and Date
      2014-07-05 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Presentation] In vivo evaluation of Gd-DTPA-incorporated calcium phosphate nanoparticles for neutron capture therapy agent2014

    • Author(s)
      N. Dewi, Yanagie H, Takahashi H.,et al.
    • Organizer
      16th International Conference on Neutron Capture Therapy
    • Place of Presentation
      Helsinki, FINLAND
    • Year and Date
      2014-06-14 – 2014-06-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 中性子捕捉療法のがん治療への応用展開2014

    • Author(s)
      柳衛宏宣
    • Organizer
      FIRST Joint International Symposium
    • Place of Presentation
      東京大学 東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Application of Liposomal Gadolinium Delivery in Neutron Capture2013

    • Author(s)
      Novriana Dewi, Yanagie H, Takahashi H.,et al.
    • Organizer
      第10回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      岡山県岡山市
    • Related Report
      2013 Research-status Report
  • [Presentation] Application of Gadolinium Drug Delivery in Neutron Capture Therapy:2013

    • Author(s)
      Novriana Dewi, Yanagie H, Takahashi H.,et al.
    • Organizer
      7th Young Researchers Meeting on NCT
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] 集学的癌治療に向けた中性子捕捉療法の応用展開

    • Author(s)
      柳衛宏宣
    • Organizer
      明治薬科大学 がんプロフェッショナル養成基盤推進事業講演会
    • Place of Presentation
      東京都清瀬市
    • Related Report
      2013 Research-status Report
    • Invited

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Published: 2014-07-25   Modified: 2019-07-29  

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