| Project/Area Number |
25670586
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TANAKA Masao 九州大学, 医学(系)研究科(研究院), 教授 (30163570)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHATA Shunichi 九州大学, 大学病院, 講師 (50437779)
UEDA Junji 佐賀大学, 医学部, 准教授 (90529801)
MANABE Tatsuya 九州大学, 医学研究院, 助教 (60546464)
SHIRAHANE Kengo 九州大学, 医学研究院, 共同研究員 (10529803)
OHUCHIDA Kenoki 九州大学, 大学病院, 助教 (20452708)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膵癌 / 膵星細胞 / 癌微小環境 / リモデリング / 治療抵抗性 / 遺伝子改変マウス / CD51 |
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| Outline of Final Research Achievements |
In genetically engineered mouse model of pancreatic cancer, the histopathological findings, including pancreatic intraepithelial neoplasia and a lot of fibrous tissue in the tumor stroma, were similar to those of human.
Integrin alpha v was widely expressed in the stroma of pancreatic cancer. Knockdown of integrin alpha v in pancreatic stellate cells decreased the production of extracellular matrix such as collagenⅠand fibronectin. PDGFA, a growth factor related to cancer-stromal interaction, and CTGF, a profibrotic growth factor, were also down-regulated by knockdown of integrin alpha v. When pancreatic cancer cells and pancreatic stellate cells were co-transplanted subcutaneously into nude mice, knockdown of integrin alpha v in pancreatic stellate cells decreased the tumor growth as compared with the control.
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