The study of lung regenerative medicine for the damaged lung by iPS cells
| Project/Area Number |
25670606
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Chiba Cancer Center (Research Institute) (2015-2016)
Chiba University (2013-2014) |
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Principal Investigator |
YAMAMOTO Takayoshi 千葉県がんセンター(研究所), 呼吸器外科, 医長 (20648349)
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| Research Collaborator |
SHIINA Yuuki 千葉大学, 大学院医学研究院, 医員 (30782304)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 肺再生 / iPS / マウス / 肺移植 / iPS細胞 / 2型肺胞上皮細胞 / II型肺胞上皮細胞 |
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| Outline of Final Research Achievements |
The purpose is that we differentiate and induce the alveolar type Ⅱ cell. We transplant these cells to disease model mouse by air way and discuss the effect.
In this duration, we could stable passage the mouse iPS cells and human iPS cells and produce the medium to differentiate and induce to the alveolar type Ⅱ cells. And we made the specific gene which could label the SP-C protein.
We now make the ischemic and reperfusion mouse model, we continue to make the experiments of the chronic immunological rejection model mouse by allograft lung transplantation.
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Report
(5 results)
Research Products
(1 results)
