Mitochondrian haplotypes and EGFR mutations in Japanese lung cancer patients
Project/Area Number |
25670609
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory surgery
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Research Institution | Kagoshima University |
Principal Investigator |
Sato Masami 鹿児島大学, 医学部, 教授 (30250830)
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Yoshihiro 鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (60381159)
KARIATSUMARI Kohta 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (20648050)
Ohtsuka Tsunayuki 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (40464466)
AOKI Masaya 鹿児島大学, 医歯学域医学系, 助教 (50624996)
NAGATA Toshiyuki 鹿児島大学, 医学部・歯学部附属病院, 医員 (70611763)
横枕 直哉 鹿児島大学, 医学部・歯学部附属病院, 助教 (50701116)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 肺癌 / 遺伝子異常 / EGFR / ミトコンドリア / ハプロタイプ / 肺癌遺伝子異常 / EGFR遺伝子 / 日本人 / EGFR遺伝子 |
Outline of Final Research Achievements |
We examined mitochondrian haplotypes and EGFR mutations in 21 Japanese lung cancer patients. EGFR mutation were observed as follows, EX19 del in 10, L858R in 9 and others in two. In these 21 cases with EGFR mutaions, mitochondrian haplotypes were as follows, D4 in7, B4 in 2, M7a in 3,G in 2,A in 1,F in 1,D5 in 1,N9a in 1,M7b in 1,B5 in 1, and M9 in 1. In conclusion, there is no relationship between mitochondrian haplotype and EGFR mutation. However, the number of examined cases was small. Thus future examination will be necessary to obtain final conclusions.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Lymphangioleiomyomatosis in a Male2015
Author(s)
Kazuhiro Wakida,Yui Watanabe,Toshio Kumasaka,Kuniaki Seyama,Keiko Mitani,Tsubasa Hiraki,Go Kamimura,Toshiyuki Nagata,Yoshihiro Nakamura,Masami Sato
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Journal Title
Ann Thorac Surg
Volume: 100
Pages: 1105-1107
Related Report
Peer Reviewed / Open Access
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[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis.2015
Author(s)
Kato H, Kurosawa K, Inoue Y, Tanuma N, Momoi Y, Hayashi K, Ogoh H, Nomura M, Sakayori M, Kakugawa Y, Yamashita Y, Miura K, Maemondo M, Katakura R, Ito S, Sato M, Sato I, Chiba N, Watanabe T, Shima H.
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Journal Title
Cancer Lett.
Volume: 365
Issue: 2
Pages: 223-228
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] 肺がん検診における喀痰細胞診の診断一致性と標準化2015
Author(s)
佐藤 雅美,柴 光年,齋藤 泰紀,佐藤 之俊,渋谷 潔,土田 敬明,中山 富雄,宝来 威,池田 徳彦,河原 栄,三浦 弘之,中嶋 隆太郎,田口 明美,矢羽田 一信,島垣 二佳子,神尾 淳子,長尾 緑,三宅 真司,下川 幸弘,田中 良太,遠藤 千顕
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Journal Title
肺癌
Volume: 55
Pages: 859-865
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Peer Reviewed / Open Access
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[Presentation] 胸腔鏡下手術での可視外臓器損傷2015
Author(s)
柳 正和,原田亜矢,鈴木聡一,梅原 正,佐藤雅美
Organizer
第38回日本呼吸器内視鏡学会
Place of Presentation
京王プラザホテル新宿(東京都新宿区)
Year and Date
2015-06-12
Related Report
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[Presentation] Pleural lymph flows by the ICG fluorescence method with near-infrared camera(A hundred cases experience)2014
Author(s)
Harada A, Nagata T,Aoki M,Harada A,Suzuki S,Umehara T,Kamimura G,Wakida K,Otsuka T,Yokomakura N,Kariatsumari K,Nakamura Y,Sato M
Organizer
18th WCBIP
Place of Presentation
Kyoto(JAPAN)
Year and Date
2014-04-14
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[Presentation] A tumor excision case of castleman disease in pulmonary hilum2014
Author(s)
Aoki M, Otsuka T,Wakida K,Umehara T,Harada A,Kamimura G,Watanabe Y,Nagata T,Yokomakura N,Kariatsumari K,Sakasegawa K,Nakamura Y,Sato M
Organizer
18th WCBIP
Place of Presentation
Kyoto(JAPAN)
Year and Date
2014-04-14
Related Report
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[Presentation] Lymphognic skip metastases and adjacent segmenntal metastases may occur in limited resection for subpleural lung cancer2014
Author(s)
Watanabe Y, Nagata T,Aoki M,Harada A,Suzuki S,Umehara T,Kamimura G,Wakida K,Otsuka T,Yokomakura N,Kariatsumari K,Nakamura Y,Sato M
Organizer
18th WCBIP
Place of Presentation
Kyoto(JAPAN)
Year and Date
2014-04-14
Related Report
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[Presentation] Novel bronchial occlusion method using an Endobronchial Watanabe Spigot for empyema with bronchopleural fistula2014
Author(s)
Nakamura Y, Kariatsumari K,Yokomakura N,Otsuka T,Nagata T,Aoki M,Watanabe Y,Wakida K,Harada A,Umehara T,Suzuki S,Sato M
Organizer
18th WCBIP
Place of Presentation
Kyoto(JAPAN)
Year and Date
2014-04-14
Related Report
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[Presentation] Ultrasonic balloon measurement and suitable stenting for air way stenosis2014
Author(s)
Otsuka T, Yanagi M,Yokomakura N,Aoki M,Harada A,Wakita K,Nagata T,Sakasegawa K,Nakamura Y,Suzuki S,Umehara T,Kamimura G,Maeda K,Watanabe Y,Kariatsumari K,Sato M
Organizer
18th WCBIP
Place of Presentation
Kyoto(JAPAN)
Year and Date
2014-04-14
Related Report
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