| Project/Area Number |
25670609
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
Sato Masami 鹿児島大学, 医学部, 教授 (30250830)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Yoshihiro 鹿児島大学, 医歯学域医学部・歯学部附属病院, 講師 (60381159)
KARIATSUMARI Kohta 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (20648050)
Ohtsuka Tsunayuki 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (40464466)
AOKI Masaya 鹿児島大学, 医歯学域医学系, 助教 (50624996)
NAGATA Toshiyuki 鹿児島大学, 医学部・歯学部附属病院, 医員 (70611763)
横枕 直哉 鹿児島大学, 医学部・歯学部附属病院, 助教 (50701116)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肺癌 / 遺伝子異常 / EGFR / ミトコンドリア / ハプロタイプ / 肺癌遺伝子異常 / ＥＧＦＲ遺伝子 / 日本人 / EGFR遺伝子 |
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| Outline of Final Research Achievements |
We examined mitochondrian haplotypes and EGFR mutations in 21 Japanese lung cancer patients. EGFR mutation were observed as follows, EX19 del in 10, L858R in 9 and others in two. In these 21 cases with EGFR mutaions, mitochondrian haplotypes were as follows, D4 in7, B4 in 2, M7a in 3，G in 2，A in 1，F in 1，D5 in 1，N9a in 1，M7b in 1，B5 in 1, and M9 in 1.
In conclusion, there is no relationship between mitochondrian haplotype and EGFR mutation. However, the number of examined cases was small. Thus future examination will be necessary to obtain final conclusions.
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