A daring attempt to cure glioblastoma by targeting glucose metabolism as a novel target to control glioma stem cells

• Project/Area Number: 25670615
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Neurosurgery
• Research Institution: Yamagata University
• Principal Investigator: KITANAKA Chifumi 山形大学, 医学部, 教授 (70260320)
• Project Period (FY): 2013-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: glioma-initiating cell

Research Abstract

Increased glucose metabolism often occurs in human cancers, the significance of which for cancer cells remains mostly unclear. In this project, we conducted experiments to test the working hypothesis that glucose metabolism has an essential role in the maintenance of glioma stem cells. The results suggested that inhibition of an intracellular molecule presumed to be involved in glucose metabolism might affect the stemness of glioma stem cells, in support of the idea that glucose metabolism is involved in the maintenance of glioma stem cells.

Research Products

• [Journal Article] JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression (2014)
  • Author(s): Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C
  • Journal Title: Int J Oncol Volume: 44 Pages: 591-599
  • Peer Reviewed
• [Journal Article] Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells (2014)
  • Author(s): Sato A, Okada M, Shibuya K, Watanabe E, Seino S, Narita Y, Shibui S, Kayama T, Kitanaka C
  • Journal Title: Stem Cell Res Volume: 12 Pages: 119-131
  • Peer Reviewed
• [Journal Article] Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells (2013)
  • Author(s): Okada M, Shibuya K, Sato A, Seino S, Watanabe E, Suzuki S, Seino M, Kitanaka C
  • Journal Title: Oncol Rep Volume: 30 Pages: 1957-1964
  • Peer Reviewed
• [Journal Article] Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells (2013)
  • Author(s): Sato A, Okada M, Shibuya K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Kayama T, Kitanaka C
  • Journal Title: Stem Cell Res Volume: 11 Pages: 601-610
  • Peer Reviewed
• [Journal Article] JNK signaling in the control of the tumor-initiating capacity associated with cancer stem cells (2013)
  • Author(s): Kitanaka C, Sato A, Okada M
  • Journal Title: Genes Cancer Volume: 4 Pages: 388-396
  • Peer Reviewed
• [Presentation] 臨床応用を目指したがん幹細胞研究.グリオーマ幹細胞を題材として (2014)
  • Author(s): 北中千史
  • Organizer: 第23回泌尿器科分子・細胞研究会特別セミナー
  • Place of Presentation: 山形(霞城セントラル)
  • Year and Date: 2014-03-15
• [Presentation] 臨床応用を見据えた悪性脳腫瘍がん幹細胞研究.がん根治療法開発を目指して (2013)
  • Author(s): 北中千史
  • Organizer: 第6回秋田脳腫瘍セミナー特別講演
  • Place of Presentation: 秋田(イヤタカ)
  • Year and Date: 2013-11-15
• [Presentation] レスベラトロールによるNanog-p53経路を介したグリオーマ幹細胞の制御 (2013)
  • Author(s): 佐藤篤,岡田雅司,渋谷慶太,清野静香,成田善孝,渋井壮一郎,北中千史,嘉山孝正
  • Organizer: 第14回日本分子脳神経外科学会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2013-10-19
• [Presentation] メトホルミンによる AMPK-FOXO3経路を介したグリオーマ幹細胞の制御 (2013)
  • Author(s): 佐藤篤,岡田雅司,成田善孝,渋井壮一郎,北中千史,嘉山孝正
  • Organizer: 日本脳神経外科学会第72回学術総会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2013-10-17
• [Presentation] A549非小細胞肺癌細胞の腫瘍形成能維持におけるJNKの特異的な役割 (2013)
  • Author(s): 岡田雅司,渋谷慶太,佐藤篤,鈴木修平,清野学,北中千史
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜(パシフィコ横浜)
  • Year and Date: 2013-10-03
• [Presentation] がん予防の今とこれから、そして未来のがん治療.がん幹細胞を標的とする新たながん治療の開発を目指して (2013)
  • Author(s): 北中千史
  • Organizer: 日本体力医学会東北地方会第22回大会
  • Place of Presentation: 山形(山形県立保健医療大学)
  • Year and Date: 2013-06-08
• [Presentation] 治療への応用を目指したグリオーマ幹細胞研究 --アップデート -- (2013)
  • Author(s): 北中千史
  • Organizer: 第46回東北脳腫瘍研究会研究会
  • Place of Presentation: 仙台(江陽グランドホテル)
  • Year and Date: 2013-04-06
  • Invited
• [Presentation] グリオーマ幹細胞 (2013)
  • Author(s): 北中千史
  • Organizer: 第8回脳腫瘍の基礎シンポジウム
  • Place of Presentation: 東京(大手町サンケイプラザ)
  • Year and Date: 2013-03-02
  • Invited
• [Presentation] グリオーマ幹細胞 (2013)
  • Author(s): 北中千史
  • Organizer: 第2回 Multidisciplinary Meeting onAtherosclerosis
  • Place of Presentation: 仙台(仙台トラストシティ)
  • Year and Date: 2013-01-05
  • Invited