| Project/Area Number |
25670615
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | glioma-initiating cell |
|---|
| Research Abstract |
Increased glucose metabolism often occurs in human cancers, the significance of which for cancer cells remains mostly unclear. In this project, we conducted experiments to test the working hypothesis that glucose metabolism has an essential role in the maintenance of glioma stem cells. The results suggested that inhibition of an intracellular molecule presumed to be involved in glucose metabolism might affect the stemness of glioma stem cells, in support of the idea that glucose metabolism is involved in the maintenance of glioma stem cells.
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