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Study on the effect of RAGE on development of hydrocephalus

Research Project

Project/Area Number 25670620
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKanazawa University

Principal Investigator

Kita Daisuke  金沢大学, 医学系, 協力研究員 (10377385)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsRAGE / 水頭症 / 白質変化 / 脳組織
Outline of Final Research Achievements

The main aim of this study was to investigate whether there is co-relation between RAGE and hydrocephalus. In endosecratory RAGE (esRAGE) transgenic mice, we identified about 3% of penetration rate of hydrocephalus, while in human hydrocephalus patients, we couldn’t find such relationship because of difficulty in measuring expression levels of esRAGE from human cerebrospinal fluid. Next, we focused on expression of esRAGE in brain and the way of enlargement of ventricular system. We found that esRAGE was expressed abundantly in human choroid plexus, though there was no relationship between the expression of RAGE and development of hydrocephalus in human. Besides RAGE study, we published two papers on developmental process of hydrocephalus in a young adult, and retention of CSF absorptive capacity in long-standing hydrocephalus patients. We presented a paper on relationship between white mater damage and hydrocephalus in the elderly in an international meeting on hydrocephalus.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (31 results)

All 2016 2015 2014 2013 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 1 results) Presentation (21 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Simultaneous ventriculoperitoneal shunt removal and endoscopic third ventriculostomy for 3 patients previously treated for intracranial germ cell tumors more than 20 years ago2016

    • Author(s)
      Daisuke Kita, Yasuhiko Hayashi, Issei Fukui, Masahiro Oishi, and Mitsutoshi Nakada
    • Journal Title

      Child's Nervous System

      Volume: [Epub ahead of print] Issue: 8 Pages: 1-4

    • DOI

      10.1007/s00381-016-3055-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 特発性正常圧水頭症、慢性硬膜下血腫2015

    • Author(s)
      喜多大輔
    • Journal Title

      認知症の最新医療

      Volume: 16 Pages: 6-12

    • Related Report
      2014 Research-status Report
  • [Journal Article] Symptomatic foramen of Magendie arachnoid cyst in an elderly patient2015

    • Author(s)
      Y. Hayashi, D. Kita, T. Watanabe, A. Yoshikawa and J. Hamada
    • Journal Title

      Surgical Neurology International

      Volume: 6 Issue: 1 Pages: 6-7

    • DOI

      10.4103/2152-7806.149611

    • NAID

      120005613976

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adenoid cystic carcinoma in the cavernous sinus diagnosed with the endoscopic endonasal approach2014

    • Author(s)
      Y. Hayashi, M. Iwato, D. Kita, K. Miyashita, T. Yoshizaki and J. Hamada
    • Journal Title

      Turkish neurosurgery

      Volume: 24 Pages: 814-818

    • DOI

      10.5137/1019-5149.jtn.9775-13.0

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endoscopic removal of subgaleal hematoma in a 7-year-old patient treated with anticoagulant and antiplatelet agents2014

    • Author(s)
      Y. Hayashi, D. Kita, T. Furuta, M. Oishi and J. Hamada
    • Journal Title

      Surgical neurology international

      Volume: 5 Issue: 1 Pages: 98-98

    • DOI

      10.4103/2152-7806.134911

    • NAID

      120005537880

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of the development of late-onset idiopathic aqueductal stenosis (LIAS) by chronological magnetic resonance imaging: a case report.2014

    • Author(s)
      Kita, D., Hayashi, Y., Kitabayashi, T., Kinoshita, M., Okajima, M., Taniguchi, T. and Hamada, J. I.
    • Journal Title

      Child's nervous system

      Volume: in press Issue: 7 Pages: 1317-1319

    • DOI

      10.1007/s00381-014-2354-2

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The mechanism of insensitivity against tyrosine kinase inhibitors in malignant glioma.2014

    • Author(s)
      Nakada M, Kita D, Watanabe T, Hayashi Y, Hamada JI.
    • Journal Title

      Brain Tumor Pahol

      Volume: 未定 Issue: 3 Pages: 8-8

    • DOI

      10.1007/s10014-013-0174-9

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regression of cerebellar tonsillar descent and hydrocephalus after endoscopic third ventriculostomy in a patient with a quadrigeminal arachnoid cyst2013

    • Author(s)
      Arakawa Y, Kita D, Ezuka I, Hayashi Y, Hamada J
    • Journal Title

      Surgical neurology international

      Volume: 4 Issue: 1 Pages: 142-142

    • DOI

      10.4103/2152-7806.119883

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapidly progressing monoparesis caused by Chiari malformation type I without syringomyelia2013

    • Author(s)
      Oishi, M., Hayashi, Y., Kita, D., Fukui, I., Shinohara, M., Heiss, J. D. and Hamada, J.
    • Journal Title

      10.4103/2152-7806.113355

      Volume: 4 Issue: 1 Pages: 79-79

    • DOI

      10.4103/2152-7806.113355

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visualization of angiographical arteriovenous shunting in perisylvian glioblastomas.2013

    • Author(s)
      Yoshikawa A, Nakada M, Kita D, Watanabe T, Kinoshita M, Miyashita K, Furuta T, Hamada JI, Uchiyama N, Hayashi Y.
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 155(4) Issue: 4 Pages: 715-719

    • DOI

      10.1007/s00701-013-1650-z

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 膵癌術後に逆行性シャント感染を来した1例―腹部術後シャント感染症例の報告とその取扱いについて2016

    • Author(s)
      喜多大輔、林 康彦、牧野 勇、朴 在鎬、中田光俊
    • Organizer
      第17回日本正常圧水頭症学会
    • Place of Presentation
      山形(山形テルサ)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] VPシャント後に両側眼瞼下垂を生じた1例2016

    • Author(s)
      喜多大輔、林 康彦、福井一生
    • Organizer
      第10回石川CSFフォーラム
    • Place of Presentation
      かほく市(かほく市中央図書館)
    • Year and Date
      2016-01-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 20年以上前にVPシャントが行われた頭蓋内胚細胞性腫瘍患者に対するシャント離脱―3例の経験より2015

    • Author(s)
      喜多大輔、林 康彦、福井一生、大石正博、中田光俊、朴 在鎬、橋本正明
    • Organizer
      第8回日本水頭症脳脊髄液学会
    • Place of Presentation
      東京(順天堂大学)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 特発性正常圧水頭症の脳室内所見に関する検討2015

    • Author(s)
      喜多大輔、林 康彦、福井一生、大石正博、中田光俊、朴 在鎬、橋本正明
    • Organizer
      第74回日本脳神経外科学会総会
    • Place of Presentation
      札幌(ロイトン札幌)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comparison between pre-operative MRI and intra-operative endoscopic findings for idiopathic normal pressure hydrocephalus2015

    • Author(s)
      D. Kita, Y. Hayashi, I. Fukui, M. Oishi, C. Park, and M. Nakada
    • Organizer
      The 7th Meeting of the International Society for Hydrocephalus and CSF Disorders
    • Place of Presentation
      Banff Springs Hotel, Banff, Canada
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵癌術後に逆行性シャント感染を来した1例2015

    • Author(s)
      喜多大輔、林 康彦、牧野 勇
    • Organizer
      第9回石川CSFフォーラム
    • Place of Presentation
      金沢(ヴィアイン金沢)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 虚血性脳血管障害と脂質異常症 特にBranch atheromatous disease(BAD)に注目して2015

    • Author(s)
      喜多大輔、南部 育、朴 在鎬、橋本正明
    • Organizer
      第18回千里浜脳循環代謝カンファレンス
    • Place of Presentation
      金沢(ホテル金沢)
    • Year and Date
      2015-05-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 特発性正常圧水頭症の内視鏡所見と画像所見に関する検討2015

    • Author(s)
      喜多大輔、林 康彦、福井一生、林 裕、中田光俊、橋本正明
    • Organizer
      第16回正常圧水頭症研究会
    • Place of Presentation
      岡山(岡山コンベンションセンター)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 妊娠中に下垂体卒中を呈し、術後管理に難渋した1例2015

    • Author(s)
      喜多大輔、佐野宏樹、岡島正樹、谷口 巧、篁 俊成、林 康彦
    • Organizer
      第42回日本集中治療医学会学術集会
    • Place of Presentation
      東京(ホテル日航東京)
    • Year and Date
      2015-02-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 以前の病歴および継時的画像が得られた若年中脳水道狭窄症の検討2014

    • Author(s)
      喜多大輔、林 康彦、福井一生、木下雅史、林 裕
    • Organizer
      第7回日本水頭症脳脊髄液学会学術集会
    • Place of Presentation
      東京(東京医科大学)
    • Year and Date
      2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 経時的画像が得られた若年中脳水道狭窄症の3例2014

    • Author(s)
      喜多大輔、林 康彦、福井一生、木下雅史、林 裕
    • Organizer
      第73回日本脳神経外科学会総会
    • Place of Presentation
      東京(グランドプリンスホテル新高輪)
    • Year and Date
      2014-10-18 – 2014-10-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 浸透圧利尿剤がETVの適応screeningに有効であった若年頭痛症例2014

    • Author(s)
      喜多大輔、林 康彦、福井一生
    • Organizer
      第23回中部神経内視鏡研究会
    • Place of Presentation
      名古屋(ウィンクあいち)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Young Adult Aqueductal Stenosis Spectrum2014

    • Author(s)
      D. Kita, Ya. Hayashi, Yu. Hayashi, M. Hashimoto
    • Organizer
      Hydorocephalus 2014
    • Place of Presentation
      Bristol University, Bristol, U.K.
    • Year and Date
      2014-09-07 – 2014-09-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 下垂体卒中にて発症したsilent mixed corticotroph and somatotoroph macroademnomaの1例2014

    • Author(s)
      喜多大輔、林 康彦、福井一生、大石正博、林 裕、丸田高広、大江真史
    • Organizer
      第20回北陸間脳下垂体腫瘍研究会
    • Place of Presentation
      金沢(都ホテル)
    • Year and Date
      2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 若年中脳水道狭窄症スペクトラム2014

    • Author(s)
      喜多大輔、林 康彦
    • Organizer
      京都髄液フォーラム2014
    • Place of Presentation
      京都(京都府立医科大学)
    • Year and Date
      2014-08-03
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脚性幻視を呈した胚細胞腫の2例2014

    • Author(s)
      喜多大輔、林 康彦、木下雅史、林 裕、濱田潤一郎
    • Organizer
      第24回日本間脳下垂体腫瘍学会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 幼少時以降に中脳水道狭窄を発症した水頭症の1例2013

    • Author(s)
      喜多大輔、林 康彦、北林朋宏、木下雅史、濱田潤一郎
    • Organizer
      第41回日本小児脳神経外科学会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Detection of late-onset idiopathic aqueductal stenosis (LIAS) by magnetic resonance images2013

    • Author(s)
      D.Kita, Y. Hayashi, T. Kitabayashi, M. Kinoshita, J. Hamada
    • Organizer
      Hydorocephalus 2013
    • Place of Presentation
      Holiday Inn, Athens (Greece)
    • Related Report
      2013 Research-status Report
  • [Presentation] 眼球運動障害で発症した下垂体腺腫の検討2013

    • Author(s)
      喜多大輔、林 康彦、福井一生、岩戸雅之、立花 修、濱田潤一郎
    • Organizer
      第72回日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 特発性中脳水道狭窄症の5例2013

    • Author(s)
      喜多大輔、林康彦、濱田潤一郎
    • Organizer
      第20回日本神経内視鏡学会
    • Place of Presentation
      甲府富士屋ホテル(甲府市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 中脳水道狭窄症 LOVA vs. LIAS

    • Author(s)
      喜多大輔、林康彦、濱田潤一郎
    • Organizer
      京都髄液フォーラム2013
    • Place of Presentation
      京都府立医大(京都市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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