| Project/Area Number |
25670634
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
SAITO Taku 東京大学, 医学部附属病院, 准教授 (30456107)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAWADA Ryoko 東京大学, 医学部附属病院, 助教 (30648308)
IKEDA Toshiyuki 東京大学, 医学部附属病院, 助教 (80322759)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 整形外科学 / 軟骨代謝 / 関節軟骨細胞 / メカニカルストレス / 軟骨代謝学 / 変形性関節症 |
|---|
| Outline of Final Research Achievements |
We first optimized experimental conditions to induce catabolic factors in mouse primary chondrocytes by cell stretch system, and analyzed gene expressions by microarray. We identified Gremlin1, which was induced by excessive cell stretch or by excessive hydrostatic pressure. Gremlin1 exerted catabolic effects in primary cultured chondrocytes and mouse knee joints, and its effects were mediated by NF-kB signaling pathway.
|
