| Project/Area Number |
25670635
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OSHIMA Yasushi 東京大学, 医学部附属病院, 講師 (50570016)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEYUKI Tanaka 東京大学, 医学部附属病院, 助教 (00583121)
上原 浩介 東京大学, 医学部附属病院, その他 (20599063)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 破骨細胞 / 骨代謝学 |
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| Outline of Final Research Achievements |
Osteoclast is a multinuclear, bone eating cell. The metabolism of bone is maintained by a subtle balance of bone formation and resorption. The collapse of this bone metabolism causes osteoporosis, arthritis and then joint destruction. It's known that Bcl-2 family which has a function of mitochondria process in apoptosis makes essential effect on osteoclast. We examined the unknown function of Mcl-1 in osteoclast which is one of Bcl-2 family protein. We elucidated that Mcl-1 has functions of positive effect on survival rate of osteoclast and negative effect on the resorption.
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