Bcl-2 family protein Mcl-1 regulates osteoclastogenesis by the anti-apoptotic function

Research Project

Project/Area Number	25670635
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Orthopaedic surgery
Research Institution	The University of Tokyo
Principal Investigator	OSHIMA Yasushi 東京大学, 医学部附属病院, 講師 (50570016)
Co-Investigator(Kenkyū-buntansha)	TAKEYUKI Tanaka 東京大学, 医学部附属病院, 助教 (00583121) 上原浩介東京大学, 医学部附属病院, その他 (20599063)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	破骨細胞 / 骨代謝学
Outline of Final Research Achievements	Osteoclast is a multinuclear, bone eating cell. The metabolism of bone is maintained by a subtle balance of bone formation and resorption. The collapse of this bone metabolism causes osteoporosis, arthritis and then joint destruction. It's known that Bcl-2 family which has a function of mitochondria process in apoptosis makes essential effect on osteoclast. We examined the unknown function of Mcl-1 in osteoclast which is one of Bcl-2 family protein. We elucidated that Mcl-1 has functions of positive effect on survival rate of osteoclast and negative effect on the resorption.