| Project/Area Number |
25670647
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
Sugano Nobuhiko 大阪大学, 医学(系)研究科(研究院), 寄附講座教授 (70273620)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI CHIKAHISA 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, その他 (40432421)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 臼蓋形成不全 / ミトコンドリアDNAハプログループ / ミトコンドリアDNAパプログループ / 臼蓋形成不全症 / ミトコンドリアDNA / ハプログループ |
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| Outline of Final Research Achievements |
We investigate the relationship between developmental dysplasia of the hip (DDH) and mitochondrial DNA haplotype in order to find one of factors which bring on DDH. One hundred and thirty nine patients were examined for mitochondrial DNA haplotype. Their distribution was compared to that of the study by Tanaka et al. (Genome Res. 2004).
Haplotype A was 10.8% in our study and 6.9% in Tanaka's report. Haplotype D was 29.5% in ours, 37.4% in Tanakas' ,respectively. Haplotype G was 12.9% in our study in compared to 6.8% in Tanaka's study. We obtained results of the difference of mitochondrial DNA haplotype distribution between patients with DDH and general japanese people. Further investigation will be conducted to reveal the relationship between DDH and mitchondrial DNA haplotype.
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