| Project/Area Number |
25670674
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Kageyama Kyouko 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (80347468)
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| Co-Investigator(Kenkyū-buntansha) |
Sawa Teiji 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013)
Nakajima Yasufumi 関西医科大学, 医学部, 教授 (70326239)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 術後回復力強化 / microRNA / 炎症消退脂質分子 / オートファジー / 遺伝子治療 / 炎症消退脂質 |
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| Outline of Final Research Achievements |
Our research aimed to elucidate the contributions of the disappearance of inflammatory responses of pro-resolving mediators and the induction of autophagy on the mechanism of Enhanced Recovery After Surgery (ERAS).
Firstly, we divided C57BL/6 mice into control and starvation groups and observed the alterations of hepatic cells. Thereafter, we identified the possibility of suppressing hepatic cell autophagy in a starved state, which was induced by Resolvin. Finally, we examined the microRNAs associated with hepatic cell autophagy in a starved state by conducting comprehensive microRNA analysis with a next generation sequencer. To the present, we have not identified microRNAs showing significant differences correlated with hepatic cell autophagy.
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