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Enhanced recovery after surgery induced by pro-resolving mediators and autophagy

Research Project

Project/Area Number 25670674
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Kageyama Kyouko  京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (80347468)

Co-Investigator(Kenkyū-buntansha) Sawa Teiji  京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013)
Nakajima Yasufumi  関西医科大学, 医学部, 教授 (70326239)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords術後回復力強化 / microRNA / 炎症消退脂質分子 / オートファジー / 遺伝子治療 / 炎症消退脂質
Outline of Final Research Achievements

Our research aimed to elucidate the contributions of the disappearance of inflammatory responses of pro-resolving mediators and the induction of autophagy on the mechanism of Enhanced Recovery After Surgery (ERAS).
Firstly, we divided C57BL/6 mice into control and starvation groups and observed the alterations of hepatic cells. Thereafter, we identified the possibility of suppressing hepatic cell autophagy in a starved state, which was induced by Resolvin. Finally, we examined the microRNAs associated with hepatic cell autophagy in a starved state by conducting comprehensive microRNA analysis with a next generation sequencer. To the present, we have not identified microRNAs showing significant differences correlated with hepatic cell autophagy.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Preoperative anesthesia clinic in Japan: a nationwide survey of the current practice of preoperative anesthesia assessment.2015

    • Author(s)
      Amaya F, Shimamoto S, Matsuda M, Kageyama K, Sawa T.
    • Journal Title

      J Anesth.

      Volume: 29 Issue: 2 Pages: 175-9

    • DOI

      10.1007/s00540-014-1918-3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] “術前外来”における患者の意識調査について2014

    • Author(s)
      影山京子、木村詩織、竹下淳、中嶋康文、伊吹京秀、佐和貞治
    • Journal Title

      麻酔

      Volume: 63 Pages: 208-14

    • NAID

      40019966334

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 「術前外来」における患者の意識調査について2014

    • Author(s)
      木村詩織、影山京子、竹下淳、中嶋康文、伊吹京秀、佐和貞治
    • Journal Title

      麻酔

      Volume: 63 Pages: 208-214

    • NAID

      40019966334

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Let’s 術前経口補水療法 スムーズに導入するための食事療養費算定に関連して2014

    • Author(s)
      影山京子、石井真紀、中嶋康文、佐和貞治
    • Journal Title

      LiSA

      Volume: 21 Pages: 278-279

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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