A genetic screen in Drosophila for regulators of human prostate cancer progression.
| Project/Area Number |
25670688
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIKI Tsuneharu 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10243239)
UEDA Takashi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50601598)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 前立腺癌 / 癌転移モデル / ショウジョウバエ / アンドロゲン |
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| Outline of Final Research Achievements |
To uncover the mechanism by which human prostate cancer progresses, we performed a genetic screen for regulators of human prostate cancer progression using the Drosophila accessory gland, a functional homolog of the mammalian prostate. Cell growth and migration of secondary cells in the adult male accessory gland were found to be regulated by Drosophila homologues of regulators of human prostate cancer progression. Using this screening system, we identified three genes that promoted growth and migration of secondary cells. The human homologues of these candidate genes were expressed in human prostate cancer cells and promoted replication and invasiveness in these cells. These findings suggest that the development of the Drosophila accessory gland and human prostate cancer cell growth and invasion are partly regulated through a common mechanism. The screening system using the accessory gland can be a useful tool for uncovering the mechanisms of human prostate cancer progression.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Hyper-expression of PAX2 in human metastatic prostate tumors and its role as a cancer promoter in an in vitro invasion model.2013
Author(s)
Ueda T, Ito S, Shiraishi T, Kulkarni P, Ueno A, Nakagawa H, Kimura Y, Hongo F, Kamoi K, Kawauchi A, Miki T.
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Journal Title
The Prostate
Volume: 73
Issue: 13
Pages: 1403-1412
DOI
Related Report
Peer Reviewed
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[Presentation] High mobility group protein AT-hook 1(HMGA1)is associated with the development of androgen independence and docetaxel-resistance in prostate cancer cells.
Author(s)
Takaha N、Sowa Y,Takeuchi I,Ueda T,Ito-Ueda S,Kimura Y,Iwata T,Nakamura T,Hongo F,Kamoi K,Okihara K,Kawauchi A,Miki T.
Organizer
2013 Annual Meeting of American Urological Association
Place of Presentation
San Diego,CA,USA
Related Report
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