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A master regulator, SATB1, regulates genes expressions in head and neck cancers

Research Project

Project/Area Number 25670713
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

Satoru Kondo  金沢大学, 大学病院, 助教 (70436822)

Co-Investigator(Kenkyū-buntansha) WAKISAKA Naohiro  金沢大学, 大学病院, 講師 (70377414)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
KeywordsSATB1 / LMP1 / EBV / 上咽頭癌 / 細胞増殖
Outline of Final Research Achievements

SATB1 is a master regulator that regulates thousand kinds of gene expressions. SATB1 associates cancer progression, invasion, and metastasis in mammalian cancer. SATB1 activates various gene expressions in mammalian cancer. However, there has been no reports that examine SATB1 expression in head and neck cancer.
In this study, we found that Epstein-Barr virus latent membrane protein-1 (EBV-LMP1) expression correlates with SATB1 expression in sample tissues with nasopharyngeal carcinoma. Moreover, we found EBV-LMP1 induces SATB1 expression in epithelial cell lines. In addition, SATB1 induced by EBV-LMP1 correlates transformation and anti-apoptosis. Finally, we also examined that SATB1 expression in other head and neck cancers and we found that SATB1 expression level of oropharygeal cancer (OPC) is higher than that of other cancers. These finding suggest SATB1 associates cancer progression, invasion, and metastasis in head and neck cancers.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 2013

All Journal Article (13 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 13 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (4 results)

  • [Journal Article] Expression of secreted protein acidic and rich in cysteine is an independent prognostic indicator of a poor clinical outcome in oropharyngeal carcinoma patients2016

    • Author(s)
      Yoshida S, Wakisaka N, Kondo S, Moriyama-Kita M, Hirai N, Endo K, Tsuji A, Nakanishi Y, Murono S, Yoshizaki T
    • Journal Title

      Acta Otolaryngol

      Volume: 136 Issue: 2 Pages: 189-94

    • DOI

      10.3109/00016489.2015.1103381

    • NAID

      120005851371

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] IL-18 is highly expressed in inflammatory infiltrates of submandibular glands in patients with immunoglobulin G4-related disease.2015

    • Author(s)
      Komori T, Kondo S, Wakisaka N, Nakanishi Y, Nakanishi-Yagi S, Tsuji A, Endo K, Murono S, Yoshizaki T.
    • Journal Title

      Hum Pathol

      Volume: 46 Issue: 12 Pages: 1850-1858

    • DOI

      10.1016/j.humpath.2015.08.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of hypermutated human papillomavirus type 16 genome by Next-Generation Sequencing.2015

    • Author(s)
      Wakae K, Aoyama S, Wang Z, Kitamura K, Liu G, Monjurul AM, Koura M, Imayasu M, Sakamoto N, Nakamura M, Kyo S, Kondo S, Fujiwara H, Yoshizaki T, Kukimoto I, Yamaguchi K, Shigenobu S, Nishiyama T, Muramatsu M.
    • Journal Title

      Virology

      Volume: 485 Pages: 460-466

    • DOI

      10.1016/j.virol.2015.08.017

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Carnitine is associated with fatigue following chemoradiotherapy for head and neck cancer.2015

    • Author(s)
      Endo K, Tsuji A, Kondo S, Wakisaka N, Murono S, Yoshizaki T.
    • Journal Title

      Acta Otolaryngol

      Volume: 45 Issue: 8 Pages: 244-247

    • DOI

      10.3109/00016489.2015.1030769

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] APOBEC3A and 3C decrease human papillomavirus 16 pseudovirion infectivity.2015

    • Author(s)
      Ahasan MM, Wakae K, Wang Z, Kitamura K, Liu G, Koura M, Imayasu M, Sakamoto N, Hanaoka K, Nakamura M, Kyo S, Kondo S, Fujiwara H, Yoshizaki T, Mori S, Kukimoto I, Muramatsu M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 457 Issue: 3 Pages: 295-9

    • DOI

      10.1016/j.bbrc.2014.12.103

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor.2015

    • Author(s)
      Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, Iizasa H.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 5 Pages: 2684-2697

    • DOI

      10.1128/jvi.03189-14

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Factors Affecting Outcomes of Alternating Chemoradiotherapy for Nasopharyngeal Cancer.2014

    • Author(s)
      Ueno T, Endo K, Kondo S
    • Journal Title

      Ann Otol Rhinol Laryngol.

      Volume: In press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes.2014

    • Author(s)
      Aga M, Bentz GL, Raffa S, Torrisi MR, Kondo S
    • Journal Title

      Oncogene

      Volume: In press Issue: 37 Pages: 4613-4622

    • DOI

      10.1038/onc.2014.66

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Closure of tracheoesophageal fistula with prefabricated deltopectoral flap.2014

    • Author(s)
      Murono S, Ishikawa E, Nakanishi Y, Endo K, Kondo S
    • Journal Title

      Asian J Surg.

      Volume: In press Issue: 4 Pages: 243-246

    • DOI

      10.1016/j.asjsur.2014.01.003

    • NAID

      120005440338

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intraoperative free jejunum flap monitoring with indocyanine green near-infrared angiography.2014

    • Author(s)
      Murono S, Ishikawa N, Ohtake H, Tsuji A, Endo K, Kondo S
    • Journal Title

      Eur Arch Otorhinolaryngol.

      Volume: In press

    • NAID

      120005411687

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma2013

    • Author(s)
      Nakanishi Y, Kondo S, Wakisaka N, Tsuji A, Endo K, Murono S, Ito M, Kitamura K, Muramatsu M and Yoshizaki T
    • Journal Title

      Plos One

      Volume: 8(4) Issue: 4 Pages: e62066-e62066

    • DOI

      10.1371/journal.pone.0062066

    • NAID

      120006602141

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical detection of SATB1 is independent of thyroid cancer differentiation.2013

    • Author(s)
      Murono S, Tsuji A, Endo K, Kondo S
    • Journal Title

      Laryngoscope

      Volume: 123 Issue: 11 Pages: 2909-2909

    • DOI

      10.1002/lary.23992

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathogenic role of Epstein-Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma.2013

    • Author(s)
      Yoshizaki T, Kondo S
    • Journal Title

      Cancer Letters

      Volume: 337 Issue: 1 Pages: 1-7

    • DOI

      10.1016/j.canlet.2013.05.018

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The expression of Sparc in Epstein-Barr virus-associated nasopharyngeal carcinoma and its relation with cell competition2014

    • Author(s)
      Satoru Kondo, Naohiro Wakisaka, Tomokazu Yoshizaki
    • Organizer
      16th International Symposium on EBV
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2014-07-16 – 2014-07-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Epstein-Barr Virus Latent Membrane Protein 1 Initiates Cancer Progenitor Cells in Nasopharyngeal Cell Lines2013

    • Author(s)
      Kondo S, Kano M, Kobayashi E, Ueno T, Pagano JS, Yoshizaki T.
    • Organizer
      6th International Symposium on Nasopharyngeal Carcinoma
    • Place of Presentation
      HIlton Istanbul (Istanbul, Turkey )
    • Related Report
      2013 Research-status Report
  • [Presentation] Epstein-Barrウィルス関連腫瘍上咽頭癌におけるSparc発現の検討-細胞競合現象の関連性-2013

    • Author(s)
      近藤 悟、小森 岳、辻 亮、遠藤 一平、脇坂 尚宏、室野 重之、吉崎 智一
    • Organizer
      第114回日本耳鼻咽喉科学会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Epstein-Barrウィルス関連腫瘍上咽頭癌におけるSparc発現の検討―EBVによる細胞競合現象の関連性について―2013

    • Author(s)
      近藤 悟、脇坂 尚宏、吉崎 智一
    • Organizer
      第72回日本癌学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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