| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
To identify roles of lymphatic circulation for salt-sensitive hypertension, we investigated the effect of a high salt diet (HSD) on mechanical function and contractility of collecting lymphatics in ex vivo studies. A HSD significantly enhanced contractility and pump activity of afferent lymphatics of SD rat iliac lymph nodes. Efferent, but not afferent, lymphatics of ICR mice iliac lymph nodes significantly increased the frequency and pump activity in response to HSD. A HSD altered responsiveness of osmolality dependent Cl- channels and TRPV channels. The present study indicates that the lymphatic system could adapt to compensate for increase in lymph flow and/or pressure after high salt loading.
|
