| Project/Area Number |
25670751
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Plastic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 血管奇形 / 動静脈奇形 / 神経系 / 細胞 / 虚血 / 組織弁 / 神経結合タンパク / 皮弁付加 / 動物モデル / 血管新生 / 遺伝子改変 / 血流 |
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| Research Abstract |
Vascular malformation is a limit of quality of life, such as limited range of motion and headache admit. Because studies have examined systematically the correlation of peripheral nerves and blood vessels , blood vessels of the circulatory system peripheral tissues and hemo- dynamics. 1. For blood flow added to the tissue to the ischemic model , the involvement of the system " nerve " , and compared with the fat stem cell population adapter of cell membrane receptor tyrosine kinase domain ( junction ) molecules (Shc -adopter protein) knockout mouse model using. 2. As a result of considering the relationship between the wound and angiogenesis and nerve regeneration, one in the lower extremities 20Gy irradiation after iliac artery ligation rat model. It is necessary to investigate further as vascular malformation approximate model by nerve -binding protein genetically engineered mouse models and ischemic rat vascular system operation.
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