| Project/Area Number |
25670766
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
INOUE YOSHIAKI 順天堂大学, 医学(系)研究科(研究院), 准教授 (60379196)
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| Co-Investigator(Kenkyū-buntansha) |
SUMI YUKA 順天堂大学, 医学部, 教授 (40403084)
西山 和孝 順天堂大学, 医学部, 助手 (80648296)
田中 裕 順天堂大学, 医学(系)研究科(研究院), 教授 (90252676)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIYAMA KAZUTAKA 順天堂大学, 医学部, 助手 (80648296)
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| Research Collaborator |
TANAKA HIROAHI 順天堂大学, 医学部, 教授 (01234567)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 気道熱傷 / バイオマーカー / IL-6 / 酸化ストレス / 白血球レオロジー / Adenosine receptor / 抗酸化能 / ATP / DIC / 生体侵襲 / oxidative stress / Endotoxin Activity Assay |
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| Outline of Final Research Achievements |
Inhalation burn is one of the major problem to influence the prognosis for the casualties of burn. Although bronchial fiverscopy has been gold standard to evaluate the severity of the inhalation burn, this examination impose patients major invasion. Therefore novel biomarker to evaluate the severity of inhalation burn would be necessary. In this study, we measured and evaluated various biomarkers for the patients with inhalation burn. IL-6 and ATP had close correlation of the severity of early phase of inhalation burn, and oxidative stress and Endotoxin Activity Assay were elevated in late complicated with sepsis.
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