Regulation and reconstruction of acquired memories in human microbiota

Research Project

Project/Area Number	25670776
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Morphological basic dentistry
Research Institution	Kyoto University (2014) Tokyo Medical and Dental University (2013)
Principal Investigator	MARUYAMA Fumito 京都大学, 医学(系)研究科(研究院), 准教授 (30423122)
Co-Investigator(Kenkyū-buntansha)	NAKAGAWA Ichiro 京都大学, 大学院医学研究科, 准教授 (70294113) KUROKAWA Ken 東京工業大学, 地球生命研究所, 准教授 (20343246) MIMURO Hitomi 東京大学, 医科学研究所, 准教授 (80396887)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	バクテリオファージ / CRISPR / 微生物生態学 / 細菌叢解析 / 外来因子
Outline of Final Research Achievements	Distribution and structure of the CRISPR, acquired immune mechanisms of bacteria, to bacteriophages, in human microbial flora are assumed that controls the robustness of its flora. As a result, CRISPR unexpectedly exist on the bacteriophage, which has been thought to not be able to coexist. It was revealed that CRISPR are distributed actually in broad range of bacterial species. This indicates that it is necessary to introduce a new concept in helping to continue to clear the robustness of the bacterial flora.